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Blood, 15 April 2008, Vol. 111, No. 8, pp. 4075-4080. Prepublished online as a Blood First Edition Paper on February 4, 2008; DOI 10.1182/blood-2007-05-091637. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-05-091637v1 111/8/4075    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Yokomizo, T. Articles by Takahashi, S. PubMed PubMed Citation Articles by Yokomizo, T. Articles by Takahashi, S. Related Collections Oncogenes and Tumor Suppressors Hematopoiesis Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS AND STEM CELLS Runx1 is involved in primitive erythropoiesis in the mouse Tomomasa Yokomizo*,1, Kazuteru Hasegawa*,1, Hiroyuki Ishitobi1, Motomi Osato2, Masatsugu Ema1, Yoshiaki Ito2, Masayuki Yamamoto1,3, and Satoru Takahashi1,4 1 Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan; 2 Institute of Molecular and Cell Biology and Oncology Research Institute, Proteos, Singapore; 3 Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan; and 4 Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan Targeted disruption of the Runx1/ AML1 gene in mice has demonstrated that it is required for the emergence of definitive hematopoietic cells but that it is not essential for the formation of primitive erythrocytes. These findings led to the conclusion that Runx1 is a stage-specific transcription factor acting only during definitive hematopoiesis. However, the zebrafish and Xenopus homologs of Runx1 have been shown to play roles in primitive hematopoiesis, suggesting that mouse Runx1 might also be involved in the development of primitive lineages. In this study, we show that primitive erythrocytes in Runx1–/– mice display abnormal morphology and reduced expression of Ter119, Erythroid Kruppel-like factor (EKLF, KLF1), and GATA-1. These results suggest that mouse Runx1 plays a role in the development of both primitive and definitive hematopoietic cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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