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Blood, 15 April 2008, Vol. 111, No. 8, pp. 4096-4105. Prepublished online as a Blood First Edition Paper on December 21, 2007; DOI 10.1182/blood-2007-05-089565. This Article Full Text Full Text (PDF) Supplemental Methods and Figure All Versions of this Article: blood-2007-05-089565v1 111/8/4096    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tjwa, M. Articles by Moons, L. Search for Related Content PubMed PubMed Citation Articles by Tjwa, M. Articles by Moons, L. Related Collections Hemostasis, Thrombosis, and Vascular Biology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes Marc Tjwa1,2, Lola Bellido-Martin3, Yuan Lin4, Esther Lutgens5, Stéphane Plaisance1,2, Françoise Bono6, Nathalie Delesque-Touchard6, Caroline Hervé6, Rute Moura7, An D. Billiau4, Cristina Aparicio3,8, Marcel Levi1,2, Mat Daemen5, Mieke Dewerchin1,2, Florea Lupu9, Jef Arnout7, Jean-Marc Herbert6, Mark Waer4, Pablo García de Frutos3,8, Björn Dahlbäck8, Peter Carmeliet1,2, Marc F. Hoylaerts7, and Lieve Moons1,2 1 Department of Transgene Technology and Gene Therapy, Flanders Institute of Biotechnology (VIB), Leuven, Belgium; 2 Center of Transgene Technology and Gene Therapy, Katholieke Universiteit (KU) Leuven, Leuven, Belgium; 3 Instituto de Investigaciones Biomédicas de Barcelona (IIBB)-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)–Consejo Superior de Investigaciones Cientificas (CSIC), Barcelona, Spain; 4 Laboratory of Experimental Transplantation, KU Leuven, Leuven, Belgium; 5 Department of Pathology, University of Maastricht, Masstricht, The Netherlands; 6 Cardiovascular-Thrombosis Research Department, Sanofi-Aventis, Toulouse, France; 7 Center of Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; 8 Department of Clinical Chemistry, University of Lund, Malmo, Sweden; and 9 Cardiovascular Research Program, Oklahoma Medical Research Foundation, Oklahoma City The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Gas6 inflames cell interactions Delphine Borgel Blood 2008 111: 3915. [Full Text] [PDF]

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