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 Blood, 15 April 2008, Vol. 111, No. 8, pp. 4264-4272.
Prepublished online as a Blood First Edition Paper on August 13, 2007; DOI 10.1182/blood-2006-10-051375.

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IMMUNOBIOLOGY

hDectin-1 is involved in uptake and cross-presentation of cellular antigens

Markus M. Weck1, Silke Appel1, Daniela Werth1, Christian Sinzger2, Anita Bringmann1, Frank Grünebach1,*, and Peter Brossart1,*

1 Department of Internal Medicine II, Division of Oncology, Hematology, Immunology, Rheumatology and Pneumology and 2 Institute of Medical Virology, University of Tübingen, Tübingen, Germany

Human Dectin-1 (hDectin-1) is a member of the C-type lectin–like receptor family that was shown to be the major receptor for fungal beta-glucans and to play an important role in the cellular responses mediated by these carbohydrates. In this study, we demonstrate that hDectin-1 is involved in the uptake and cross-presentation of cellular antigens. Furthermore, activation of monocyte-derived dendritic cells (MDCs) with toll-like receptor 3 (TLR3) ligand but not with TLR2 ligand or TLR7 ligand resulted in down-regulation of hDectin-1 expression and reduced phagocytosis of apoptotic tumor cells as well as presentation of pp65-derived T-cell epitopes upon engulfment of cytomegalovirus (CMV)–infected human foreskin fibroblasts.


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