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Blood, 15 November 2008, Vol. 112, No. 10, pp. 3995-4002. Prepublished online as a Blood First Edition Paper on August 28, 2008; DOI 10.1182/blood-2008-05-155960. This Article Full Text Full Text (PDF) Supplemental Appendix and Table All Versions of this Article: blood-2008-05-155960v1 112/10/3995    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bartman, M. T. Articles by Murphy, E. L. Search for Related Content PubMed PubMed Citation Articles by Bartman, M. T. Articles by Murphy, E. L. Related Collections Hematopoiesis and Stem Cells Immunobiology Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection Melissa T. Bartman1,2, Zhanna Kaidarova2, Dale Hirschkorn2, Ronald A. Sacher3, Joy Fridey4, George Garratty5, Joan Gibble6, James W. Smith7, Bruce Newman8, Anthony E. Yeo2, Edward L. Murphy2,9, for the HTLV Outcomes Study (HOST) investigators 1 School of Public Health, University of California, Berkeley; 2 Blood Systems Research Institute, San Francisco, CA; 3 Hoxworth Blood Center, University of Cincinnati, OH; 4 City of Hope Medical Center, Duarte, CA; 5 American Red Cross Blood Services, Southern California Region, Pomona; 6 American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, MD; 7 Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City; 8 American Red Cross Blood Services, Southeastern Michigan Region, Detroit; and 9 University of California at San Francisco Human T-lymphotropic viruses types I and II (HTLV-I and HTLV-II) cause chronic infections of T lymphocytes that may lead to leukemia and myelopathy. However, their long-term effects on blood counts and hematopoiesis are poorly understood. We followed 151 HTLV-I–seropositive, 387 HTLV-II–seropositive, and 799 HTLV-seronegative former blood donors from 5 U.S. blood centers for a median of 14.0 years. Complete blood counts were performed every 2 years. Multivariable repeated measures analyses were conducted to evaluate the independent effect of HTLV infection and potential confounders on 9 hematologic measurements. Participants with HTLV-II had significant (P < .05) increases in their adjusted lymphocyte counts (+126 cells/mm3; approximately +7%), hemoglobin (+2 g/L [+0.2 g/dL]) and mean corpuscular volume (MCV; 1.0 fL) compared with seronegative participants. Participants with HTLV-I and HTLV-II had higher adjusted platelet counts (+16 544 and +21 657 cells/mm3; P < .05) than seronegatives. Among all participants, time led to decreases in platelet count and lymphocyte counts, and to increases in MCV and monocytes. Sex, race, smoking, and alcohol consumption all had significant effects on blood counts. The HTLV-II effect on lymphocytes is novel and may be related to viral transactivation or immune response. HTLV-I and HTLV-II associations with higher platelet counts suggest viral effects on hematopoietic growth factors or cytokines. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Hematologic hints of HTLV-2 in US blood donors Mark A. Beilke Blood 2008 112: 3919-3920. [Full Text] [PDF] This article has been cited by other articles: G. Besson and M. Kazanji One-Step, Multiplex, Real-Time PCR Assay with Molecular Beacon Probes for Simultaneous Detection, Differentiation, and Quantification of Human T-Cell Leukemia Virus Types 1, 2, and 3 J. Clin. Microbiol., April 1, 2009; 47(4): 1129 - 1135. [Abstract] [Full Text] [PDF]

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