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Blood, 15 November 2008, Vol. 112, No. 10, pp. 4284-4291. Prepublished online as a Blood First Edition Paper on August 11, 2008; DOI 10.1182/blood-2008-04-154112. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-04-154112v1 112/10/4284    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cohen, R. M. Articles by Joiner, C. H. Search for Related Content PubMed PubMed Citation Articles by Cohen, R. M. Articles by Joiner, C. H. Related Collections Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c Robert M. Cohen1, Robert S. Franco2,3, Paramjit K. Khera1, Eric P. Smith1, Christopher J. Lindsell4, Peter J. Ciraolo2,3, Mary B. Palascak2,3, and Clinton H. Joiner2,5 1 Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, 2 Cincinnati Comprehensive Sickle Cell Center, Division of Hematology/Oncology, 3 Division of Hematology/Oncology, 4 Department of Emergency Medicine, and 5 Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH Although red blood cell (RBC) life span is a known determinant of percentage hemoglobin A1c (HbA1c), its variation has been considered insufficient to affect clinical decisions in hematologically normal persons. However, an unexplained discordance between HbA1c and other measures of glycemic control can be observed that could be, in part, the result of differences in RBC life span. To explore the hypothesis that variation in RBC life span could alter measured HbA1c sufficiently to explain some of this discordance, we determined RBC life span using a biotin label in 6 people with diabetes and 6 nondiabetic controls. Mean RBC age was calculated from the RBC survival curve for all circulating RBCs and for labeled RBCs at multiple time points as they aged. In addition, HbA1c in magnetically isolated labeled RBCs and in isolated transferrin receptor-positivereticulocytes was used to determine the in vivo synthetic rate of HbA1c. The mean age of circulating RBCs ranged from 39 to 56 days in diabetic subjects and 38 to 60 days in nondiabetic controls. HbA1c synthesis was linear and correlated with mean whole blood HbA1c (R2 = 0.91). The observed variation in RBC survival was large enough to cause clinically important differences in HbA1c for a given mean blood glucose. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. H Nash, A. R Kristal, B. B Boyer, I. B King, J. S Metzgar, and D. M O'Brien Relation between stable isotope ratios in human red blood cells and hair: implications for using the nitrogen isotope ratio of hair as a biomarker of eicosapentaenoic acid and docosahexaenoic acid Am. J. Clinical Nutrition, December 1, 2009; 90(6): 1642 - 1647. [Abstract] [Full Text] [PDF] A. Bonnefond, M. Vaxillaire, Y. Labrune, C. Lecoeur, J.-C. Chevre, N. Bouatia-Naji, S. Cauchi, B. Balkau, M. Marre, J. Tichet, et al. Genetic Variant in HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control-Related Traits Diabetes, November 1, 2009; 58(11): 2687 - 2697. [Abstract] [Full Text] [PDF] B. A. Rowan and A. J. Bendich The loss of DNA from chloroplasts as leaves mature: fact or artefact? J. Exp. Bot., July 1, 2009; 60(11): 3005 - 3010. [Abstract] [Full Text] [PDF]

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