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Blood, 15 November 2008, Vol. 112, No. 10, pp. 4314-4317. Prepublished online as a Blood First Edition Paper on September 4, 2008; DOI 10.1182/blood-2008-03-143891. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2008-03-143891v1 112/10/4314    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bernaudin, F. Articles by Delacourt, C. Search for Related Content PubMed PubMed Citation Articles by Bernaudin, F. Articles by Delacourt, C. Related Collections Red Cells Brief Reports Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Brief Report G6PD deficiency, absence of -thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia Françoise Bernaudin1, Suzanne Verlhac2, Sylvie Chevret3, Martine Torres4, Lena Coic1, Cécile Arnaud1, Annie Kamdem1, Isabelle Hau1, Maria Grazia Neonato5, and Christophe Delacourt1 1 Reference Center for Sickle Cell Disease, Department of Pediatrics, and 2 Medical Imagerie, Department of Radiology, Intercommunal Créteil Hospital, Créteil, France; 3 Department of Statistics, St-Louis Hospital, Paris, France; 4 Pediatrics, University of Southern California, Los Angeles; and 5 Hematology, Molecular Biology, Tenon Hospital, Paris, France Stroke is predicted by abnormally high cerebral velocities by transcranial doppler (TCD). This study aimed at defining predictive factors for abnormally high velocities ( 2 m/sec) based on the Créteil pediatric sickle cell anemia (SCA) cohort composed of 373 stroke-free SCA children. genes and β-globin haplotypes were determined. Biologic parameters were obtained at baseline. -thalassemia was present in 155 of 325 and G6PD deficiency in 36 of 325 evaluated patients. TCD was abnormal in 62 of 373 patients. Multivariate logistic regression analysis showed that G6PD deficiency (odds ratio [OR] = 3.36, 95% confidence interval [CI] 1.10-10.33; P = .034), absence of alpha-thalassemia (OR = 6.45, 95% CI 2.21-18.87; P = .001), hemoglobin (OR per g/dL = 0.63, 95% CI 0.41-0.97; P = .038), and lactate dehydrogenase (LDH) levels (OR per IU/L = 1.001, 95% CI 1.000-1.002; P = .047) were independent risk factors for abnormally high velocities. This study confirms the protective effect of alpha-thalassemia and shows for the first time that G6PD deficiency and hemolysis independently increase the risk of cerebral vasculopathy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Glucose 6 phosphate dehydrogenase deficiency is not associated with cerebrovascular disease in children with sickle cell anemia David C. Rees, Christopher Lambert, Elaine Cooper, Jack Bartram, David Goss, Colin Deane, and Swee Lay Thein Blood 2009 114: 742-743. [Full Text] [PDF] This article has been cited by other articles: D. C. Rees, C. Lambert, E. Cooper, J. Bartram, D. Goss, C. Deane, and S. L. Thein Glucose 6 phosphate dehydrogenase deficiency is not associated with cerebrovascular disease in children with sickle cell anemia Blood, July 16, 2009; 114(3): 742 - 743. [Full Text] [PDF]

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