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Blood, 1 December 2008, Vol. 112, No. 12, pp. 4401-4410. Prepublished online as a Blood First Edition Paper on September 9, 2008; DOI 10.1182/blood-2008-02-140426. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-02-140426v1 112/12/4401    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cagigi, A. Articles by Nilsson, A. Search for Related Content PubMed PubMed Citation Articles by Cagigi, A. Articles by Nilsson, A. Related Collections Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES, CYTOKINES, AND INTERLEUKINS Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection Alberto Cagigi1,*, Frida Mowafi1,*, Linh V. Phuong Dang1, Klara Tenner-Racz2, Ann Atlas3, Sven Grutzmeier1,4, Paul Racz2, Francesca Chiodi1, and Anna Nilsson1,5 1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; 2 Department of Pathology and the Körber Laboratory for AIDS Research, Berhard-Nocht Institute for Tropical Diseases, Hamburg, Germany; 3 Department of Medicine Solna, Infectious Diseases Unit, Karolinska University Hospital, Stockholm, Sweden; 4 Gay Men's Health Clinic, Soder Hospital, Stockholm, Sweden; and 5 Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden HIV-1 infection is associated with B-cell abnormalities, such as hypergammaglobulinemia, poor immunization responses, and loss of serologic memory. To determine whether altered expression of chemokine receptors and their ligands may play a role in B-cell dysfunctions during HIV-1 infection, the expression of CXC chemokine receptor 4 (CXCR4), CXCR5, and CC chemokine receptor 7 (CCR7) and their respective ligands on CD19+ B cells were examined in HIV-1–infected patients and controls. We report a decreased CXCR5 expression on B cells from patients (P < .05), a phenomenon associated with a low CD4 T-cell count (< 350 cells/µL). Interestingly, an increased expression of CXC chemokine ligand 13 (CXCL13), the ligand for CXCR5, was found in peripheral B cells from HIV-1–infected patients. Moreover, on B-cell activation in vitro, CXCL13 was secreted in culture. CXCL13+ B cells were also found in the lymph nodes of HIV-1–infected patients, but not in control tissue. B-cell migration toward CXCL13, CXCL12, and CC chemokine ligand 21 (CCL21), ligands for CXCR5, CXCR4, and CCR7 was also evaluated. In patients with a low CD4 T-cell count, migration toward all ligands was increased. Our findings indicate that altered expression of the chemokine receptor-ligand pair, CXCR5/CXCL13, may participate in the establishment of B-cell dysfunctions during HIV-1 infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Pensieroso, A. Cagigi, P. Palma, A. Nilsson, C. Capponi, E. Freda, S. Bernardi, R. Thorstensson, F. Chiodi, and P. Rossi From the Cover: Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children PNAS, May 12, 2009; 106(19): 7939 - 7944. [Abstract] [Full Text] [PDF]

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