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Blood, 15 December 2008, Vol. 112, No. 13, pp. 4793-4807. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dick, J. E. Search for Related Content PubMed PubMed Citation Articles by Dick, J. E. Related Collections Hematopoiesis and Stem Cells Neoplasia Free Research Articles ASH 50th Anniversary Reviews Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  ASH 50TH ANNIVERSARY REVIEW Stem cell concepts renew cancer research John E. Dick1 1 Division of Cell and Molecular Biology, University Health Network, and Department of Molecular Genetics, University of Toronto, Toronto, ON Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the individual cells that make up the tumor exhibit considerable variation in many properties, including morphology, proliferation kinetics, and the ability to initiate tumor growth in transplant assays. Understanding the molecular and cellular basis of this heterogeneity has important implications in the design of therapeutic strategies. The mechanistic basis of tumor heterogeneity has been uncertain; however, there is now strong evidence that cancer is a cellular hierarchy with cancer stem cells at the apex. This review provides a historical overview of the influence of hematology on the development of stem cell concepts and their linkage to cancer. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D Mullassery, C Dominici, E C Jesudason, H P McDowell, and P D Losty Neuroblastoma: contemporary management Arch. Dis. Child. Ed. Pract., December 1, 2009; 94(6): 177 - 185. [Full Text] [PDF] C. Milsom, N. Magnus, B. Meehan, K. Al-Nedawi, D. Garnier, and J. Rak Tissue Factor and Cancer Stem Cells: Is There a Linkage? Arterioscler Thromb Vasc Biol, December 1, 2009; 29(12): 2005 - 2014. [Abstract] [Full Text] [PDF] A. Tefferi and J. W. Vardiman Myelodysplastic Syndromes N. Engl. J. Med., November 5, 2009; 361(19): 1872 - 1885. [Full Text] [PDF] M. Heuser, L. M. Sly, B. Argiropoulos, F. Kuchenbauer, C. Lai, A. Weng, M. Leung, G. Lin, C. Brookes, S. Fung, et al. Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal Blood, November 5, 2009; 114(19): 3983 - 3993. [Abstract] [Full Text] [PDF] C. J. Creighton, X. Li, M. Landis, J. M. Dixon, V. M. Neumeister, A. Sjolund, D. L. Rimm, H. Wong, A. Rodriguez, J. I. Herschkowitz, et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features PNAS, August 18, 2009; 106(33): 13820 - 13825. [Abstract] [Full Text] [PDF] P. P. Levings, S. V. McGarry, T. P. Currie, D. M. Nickerson, S. McClellan, S. C. Ghivizzani, D. A. Steindler, and C. P. Gibbs Expression of an Exogenous Human Oct-4 Promoter Identifies Tumor-Initiating Cells in Osteosarcoma Cancer Res., July 15, 2009; 69(14): 5648 - 5655. [Abstract] [Full Text] [PDF] J. M. Rosen and C. T. Jordan The Increasing Complexity of the Cancer Stem Cell Paradigm Science, June 26, 2009; 324(5935): 1670 - 1673. [Abstract] [Full Text] [PDF] M. Merad and M. G. Manz Dendritic cell homeostasis Blood, April 9, 2009; 113(15): 3418 - 3427. [Abstract] [Full Text] [PDF]

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