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 Blood, 15 December 2008, Vol. 112, No. 13, pp. 5037-5045.
Prepublished online as a Blood First Edition Paper on September 19, 2008; DOI 10.1182/blood-2008-04-149526.

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IMMUNOBIOLOGY

Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering

Phyllis J. Fisher1, Peggy A. Bulur1, Stanimir Vuk-Pavlovic1, Franklyn G. Prendergast1, and Allan B. Dietz1

1 Mayo Clinic, Rochester, MN

Polarizing effects of productive dendritic cell (DC)–T-cell interactions on DC cytoskeleton have been known in some detail, but the effects on DC membrane have been studied to a lesser extent. We found that T-cell incubation led to DC elongation and segregation of characteristic DC veils to the broader pole of the cell. On the opposite DC pole, we observed a novel membrane feature in the form of bundled microvilli. Each villus was approximately 100 nm in diameter and 600 to 1200 nm long. Microvilli exhibited high density of antigen-presenting molecules and costimulatory molecules and provided the physical basis for the multifocal immune synapse we observed during human DC and T-cell interactions. T cells preferentially bound to this site in clusters often contained both CD4+ and CD8+ T cells.


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