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Blood, 15 December 2008, Vol. 112, No. 13, pp. 5074-5083. Prepublished online as a Blood First Edition Paper on September 2, 2008; DOI 10.1182/blood-2008-01-132787. This Article Full Text Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2008-01-132787v1 112/13/5074    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wakkach, A. Articles by Blin-Wakkach, C. Search for Related Content PubMed PubMed Citation Articles by Wakkach, A. Articles by Blin-Wakkach, C. Related Collections Immunobiology Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts Abdelilah Wakkach1, Anna Mansour1, Romain Dacquin2, Emmanuel Coste1, Pierre Jurdic2, Georges F. Carle1,*, and Claudine Blin-Wakkach1,* 1 GEPITOS, Université de Nice Sophia Antipolis, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 6235, Faculté de Médecine, Nice; and 2 Laboratoire de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Ecole Normale Supérieure, Unite Mixte de Recherche 5161, Lyon, France Finding that activated T cells control osteoclast (OCL) differentiation has revealed the importance of the interactions between immune and bone cells. Dendritic cells (DCs) are responsible for T-cell activation and share common precursors with OCLs. Here we show that DCs participate in bone resorption more directly than simply through T-cell activation. We show that, among the splenic DC subsets, the conventional DCs have the higher osteoclastogenic potential in vitro. We demonstrate that conventional DCs differentiate into functional OCLs in vivo when injected into osteopetrotic oc/oc mice defective in OCL resorptive function. Moreover, this differentiation involves the presence of activated CD4+ T cells controlling a high RANK-L expression by bone marrow stromal cells. Our results open new insights in the differentiation of OCLs and DCs and offer new basis for analyzing the relations between bone and immune systems. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Dendritic cells differentiate into osteoclasts in bone marrow microenvironment in vivo Mawadda Alnaeeli and Yen-Tung A. Teng Blood 2009 113: 264-265. [Full Text] [PDF] More on the differentiation of dendritic cells into osteoclasts Abdelilah Wakkach and Claudine Blin-Wakkach Blood 2009 113: 265. [Full Text] [PDF] This article has been cited by other articles: A. Kukreja, S. Radfar, B.-H. Sun, K. Insogna, and M. V. Dhodapkar Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease Blood, October 15, 2009; 114(16): 3413 - 3421. [Abstract] [Full Text] [PDF] M. Alnaeeli and Y.-T. A. Teng Dendritic cells differentiate into osteoclasts in bone marrow microenvironment in vivo Blood, January 1, 2009; 113(1): 264 - 265. [Full Text] [PDF] A. Wakkach and C. Blin-Wakkach More on the differentiation of dendritic cells into osteoclasts Blood, January 1, 2009; 113(1): 265 - 265. [Full Text] [PDF]

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