SEARCH:   Advanced

Blood, 15 December 2008, Vol. 112, No. 13, pp. 5241-5244. Prepublished online as a Blood First Edition Paper on September 29, 2008; DOI 10.1182/blood-2008-06-165738. This Article Full Text Full Text (PDF) Supplemental Table and Figure All Versions of this Article: blood-2008-06-165738v1 112/13/5241    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tamary, H. Articles by Miller, J. L. Search for Related Content PubMed PubMed Citation Articles by Tamary, H. Articles by Miller, J. L. Related Collections Red Cells Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Brief report Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I Hannah Tamary1, Hanna Shalev2, Galit Perez-Avraham2, Meira Zoldan1, Itai Levi2, Dorine W. Swinkels3, Toshihiko Tanno4, and Jeffery L. Miller4 1 Hematology Oncology Center, Schneider Children's Medical Center of Israel Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 2 Hematology Soroka Medical Center, Faculty of Medicine, Ben-Gurion University, Beer Sheva, Israel; 3 Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; and 4 Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD Congenital dyserythropoietic anemia (CDA) is a rare group of red blood cell disorders characterized by ineffective erythropoiesis and increased iron absorption. To determine whether growth differentation factor 15 (GDF15) hyper-expression is associated with the ineffective erythropoiesis and iron-loading complications of CDA type I (CDA I), GDF15 levels and other markers of erythropoiesis and iron overload were studied in blood from 17 CDA I patients. Significantly higher levels of GDF15 were detected among the CDA I patients (10 239 ± 3049 pg/mL) compared with healthy volunteers (269 ± 238 pg/mL). In addition, GDF15 correlated significantly with several erythropoietic and iron parameters including Hepcidin-25, Ferritin, and Hepcidin-25/Ferritin ratios. These novel results suggest that CDA I patients express very high levels of serum GDF15, and that GDF15 contributes to the inappropriate suppression of hepcidin with subsequent secondary hemochromatosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Iolascon and J. Delaunay Close to unraveling the secrets of congenital dyserythropoietic anemia types I and II Haematologica, May 1, 2009; 94(5): 599 - 602. [Full Text] [PDF] C. Camaschella and E. Poggiali Towards explaining "unexplained hyperferritinemia" Haematologica, March 1, 2009; 94(3): 307 - 309. [Full Text] [PDF]

	Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020