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Blood, 15 July 2008, Vol. 112, No. 2, pp. 435-443. Prepublished online as a Blood First Edition Paper on April 2, 2008; DOI 10.1182/blood-2008-01-132902. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-01-132902v1 112/2/435    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Foley, B. A. Articles by Witt, C. S. Search for Related Content PubMed PubMed Citation Articles by Foley, B. A. Articles by Witt, C. S. Related Collections Immunobiology Transplantation Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION The reactivity of Bw4+ HLA-B and HLA-A alleles with KIR3DL1: implications for patient and donor suitability for haploidentical stem cell transplantations Bree A. Foley1, Dianne De Santis1,2, Els Van Beelen3, Louise J. Lathbury1, Frank T. Christiansen1,2, and Campbell S. Witt2 1 School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia; 2 Department of Clinical Immunology and Immunogenetics, PathWest Royal Perth Hospital, Perth, Australia; and 3 Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands Natural killer (NK)–cell alloreactivity can be exploited in haploidentical hematopoietic stem cell transplantation (HSCT). NK cells from donors whose HLA type includes Bw4, a public epitope present on a subset of HLA-B alleles, can be alloreactive toward recipients whose cells lack Bw4. Serologically detectable epitopes related to Bw4 also exist on a subset of HLA-A alleles, but the interaction of these alleles with KIR3DL1 is controversial. We therefore undertook a systematic analysis of the ability of most common HLA-B alleles and HLA-A alleles with Bw4 serologic reactivity to protect target cells from lysis by KIR3DL1-dependent NK cells. All Bw4– HLA-B alleles failed to protect target cells from lysis. All Bw4+ HLA-B alleles with the exception of HLA-B*1301 and -B*1302 protected targets from lysis. HLA-A*2402 and HLA-A*3201 unequivocally protected target cells from lysis, whereas HLA-A*2501 and HLA-A*2301 provided only weak protection from lysis. KIR3DL1-dependent alloreactive NK clones were identified in donors with HLA-A*2402 but not in donors with HLA-B*1301 or -B*1302. These findings clarify the HLA types that donors and recipients need in haploidentical HSCT and other NK allotherapies in order to benefit from NK alloreactivity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: How killers kill Jeffrey S. Miller Blood 2008 112: 213. [Full Text] [PDF] This article has been cited by other articles: S. Andersson, C. Fauriat, J.-A. Malmberg, H.-G. Ljunggren, and K.-J. Malmberg KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression Blood, July 2, 2009; 114(1): 95 - 104. [Abstract] [Full Text] [PDF] M. Morvan, C. Willem, K. Gagne, N. Kerdudou, G. David, V. Sebille, G. Follea, J.-D. Bignon, and C. Retiere Phenotypic and Functional Analyses of KIR3DL1+ and KIR3DS1+ NK Cell Subsets Demonstrate Differential Regulation by Bw4 Molecules and Induced KIR3DS1 Expression on Stimulated NK Cells J. Immunol., June 1, 2009; 182(11): 6727 - 6735. [Abstract] [Full Text] [PDF] C. G. Brunstein, J. E. Wagner, D. J. Weisdorf, S. Cooley, H. Noreen, J. N. Barker, T. DeFor, M. R. Verneris, B. R. Blazar, and J. S. Miller Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity Blood, May 28, 2009; 113(22): 5628 - 5634. [Abstract] [Full Text] [PDF] P. J. Norman, L. Abi-Rached, K. Gendzekhadze, J. A. Hammond, A. K. Moesta, D. Sharma, T. Graef, K. L. McQueen, L. A. Guethlein, C. V.F. Carrington, et al. Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes Genome Res., May 1, 2009; 19(5): 757 - 769. [Abstract] [Full Text] [PDF] J. Yu, J. M. Venstrom, X.-R. Liu, J. Pring, R. S. Hasan, R. J. O'Reilly, and K. C. Hsu Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell-depleted allogeneic hematopoietic cell transplantation Blood, April 16, 2009; 113(16): 3875 - 3884. [Abstract] [Full Text] [PDF] M. Yawata, N. Yawata, M. Draghi, F. Partheniou, A.-M. Little, and P. Parham MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response Blood, September 15, 2008; 112(6): 2369 - 2380. [Abstract] [Full Text] [PDF]

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