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Blood, 1 September 2008, Vol. 112, No. 5, pp. 1776-1783. Prepublished online as a Blood First Edition Paper on June 25, 2008; DOI 10.1182/blood-2008-02-135871. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2008-02-135871v1 112/5/1776    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Agaugué, S. Articles by Moretta, A. Search for Related Content PubMed PubMed Citation Articles by Agaugué, S. Articles by Moretta, A. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells Sophie Agaugué1, Emanuela Marcenaro1, Bruna Ferranti1, Lorenzo Moretta13, and Alessandro Moretta1,3 1 Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genoa; 2 Istituto Giannina Gaslini, Genoa; and 3 Centro di Eccellenza per le Ricerche Biomediche, Università degli studi di Genova, Genoa, Italy Dendritic cells (DCs) play a crucial role in naive T-cell priming. Recent data suggested that natural killer (NK) cells can influence the capability of DCs to promote Th1 polarization. This regulatory function is primarily mediated by cytokines released in the microenvironment during inflammatory responses involving NK cells. In this study, we show that human NK cells exposed for short time to interleukin (IL)–12, IL-2, or IL-18, promote distinct pathways of Th1 priming. IL-12– or IL-2–conditioned NK cells induce maturation of DCs capable of priming IFN-–producing Th1 cells. On the other hand, IL-18–conditioned NK cells induce Th1 polarization only when cocultured with both DCs and T cells. In this case, IL-2 released by T cells and IL-12 derived from DCs during the priming process promote interferon (IFN)– production. In contrast, when NK cells are exposed to IL-4, nonpolarized T cells releasing only low levels of IL-2 are generated. Thus, the prevalence of IL-12, IL-2, IL-18, or IL-4 at inflammatory sites may differentially modulate the NK-cell interaction with DCs, leading to different outcomes in naive T-cell polarization. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Marcenaro, C. Cantoni, S. Pesce, C. Prato, D. Pende, S. Agaugue, L. Moretta, and A. Moretta Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction Blood, November 5, 2009; 114(19): 4108 - 4116. [Abstract] [Full Text] [PDF]

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