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Blood, 15 September 2008, Vol. 112, No. 6, pp. 2411-2420. Prepublished online as a Blood First Edition Paper on May 27, 2008; DOI 10.1182/blood-2008-02-140335. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-02-140335v1 blood-2008-02-140335v2 112/6/2411    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sabouri, A. H. Articles by Saito, M. Search for Related Content PubMed PubMed Citation Articles by Sabouri, A. H. Articles by Saito, M. Related Collections Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Impaired function of human T-lymphotropic virus type 1 (HTLV-1)–specific CD8+ T cells in HTLV-1–associated neurologic disease Amir H. Sabouri1, Koichiro Usuku2, Daisuke Hayashi1, Shuji Izumo3, Yoshiro Ohara4, Mitsuhiro Osame1, and Mineki Saito4 1 Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima; 2 Department of Medical Information Technology and Administration Planning, Kumamoto University Hospital, Kumamoto; 3 Center for Chronic Viral Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima; and 4 Department of Microbiology, Kanazawa Medical University, Ishikawa, Japan Despite abundant activated virus-specific cytotoxic T lymphocytes (CTLs), patients with human T-lymphotropic virus type 1 (HTLV-1)–associated myelopathy/tropical spastic paraparesis (HAM/TSP) showed a significantly higher frequency of infected T cells than did healthy virus carriers (HVCs). Here, we demonstrate that at a given proviral load, the frequency of CD8+ T cells that are negative for specific costimulatory molecules was significantly higher in HAM/TSP than in age-matched HVCs and uninfected healthy controls (HCs), whereas the frequency of intracellular perforin-positive CD8+ T cells was significantly lower in both HAM/TSP and HVCs than in HCs. An inverse correlation between HTLV-1 proviral load (PVL) and percent perforin-positive CD8+ T cells were observed only in disease-protective allele HLA-A*02–positive HVCs, but not in HAM/TSP patients, whether HLA-A*02 positive or negative, nor in HLA-A*02–negative HVCs. Significantly lower perforin expression was observed in HTLV-1–specific than in cytomegalovirus-specific CD8+ T cells. Majority of HTLV-1–specific CD8+ T cells in HVCs showed a CD28–CD27+ phenotype, whereas HAM/TSP showed a CD28–CD27– phenotype. HTLV-1–specific CD8+ T cells from HAM/TSP patients showed significantly lower degranulation than HVCs by CD107a mobilization assay. These findings suggest that an impaired function of HTLV-1–specific CTLs is associated with failing antiviral control and disease HAM/TSP. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: HTLV-1 infection: role of CTL efficiency Charles R. M. Bangham Blood 2008 112: 2176-2177. [Full Text] [PDF] This article has been cited by other articles: T. Kattan, A. MacNamara, A. G. Rowan, H. Nose, A. J. Mosley, Y. Tanaka, G. P. Taylor, B. Asquith, and C. R. M. Bangham The Avidity and Lytic Efficiency of the CTL Response to HTLV-1 J. Immunol., May 1, 2009; 182(9): 5723 - 5729. [Abstract] [Full Text] [PDF]

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