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Blood, 15 September 2008, Vol. 112, No. 6, pp. 2579-2582. Prepublished online as a Blood First Edition Paper on June 23, 2008; DOI 10.1182/blood-2007-11-118893. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2007-11-118893v1 blood-2007-11-118893v2 112/6/2579    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Narimatsu, H. Articles by Kato, S. Search for Related Content PubMed PubMed Citation Articles by Narimatsu, H. Articles by Kato, S. Related Collections Transplantation Free Research Articles Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief Report Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan Hiroto Narimatsu1, Shigesaburo Miyakoshi2, Takuhiro Yamaguchi3, Masahiro Kami1, Tomoko Matsumura2, Koichiro Yuji2, Naoko Murashige4, Eiji Kusumi5, Yuko Kodama1, Tsunehiko Komatsu6, Hisashi Sakamaki7, Yasushi Kouzai8, Masaya Okada9, Yuko Osugi10, Ryoji Kobayashi11, Masami Inoue12, Satoshi Takahashi13, Shunro Kai2, Koji Kato2, Tokiko Inoue-Nagamura2, Shuichi Taniguchi2, Shunichi Kato2, for the Japan Cord Blood Bank Network 1 Divison of Exploratory Research, Institute of Medical Science, The University of Tokyo, Tokyo; 2 Japan Cord Blood Bank Network, Tokyo; 3 Department of Clinical Trial Data Management, Graduate School of Medicine, The University of Tokyo, Tokyo; 4 Office for Life-Style Related Diseases Control, Ministry of Health, Labor and Welfare, Tokyo; 5 Department of Hematology, Toranomon Hospital, Tokyo; 6 The Third Department of Internal Medicine, Teikyo University School of Medicine, Tokyo; 7 Division of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo; 8 Department of Transfusion, Tokyo Metropolitan Fuchu Hospital, Tokyo; 9 Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya; 10 Department of Pediatric Oncology/Hematology, Osaka City General Hospital, Osaka; 11 Department of Paediatrics, Hokkaido University Graduate School of Medicine, Sapporo; 12 Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka; and 13 Division of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan We have little information on chronic graft-versus-host disease (GVHD) after cord blood transplantation (CBT). We investigated its clinical features in 1072 Japanese patients with hematologic malignancies who received a transplant through the Japan Cord Blood Bank Network. The primary end point was to investigate the incidence of any chronic GVHD. Median age of the patients was 33 years (range, 0-79 years). The cumulative incidence of chronic GVHD 2 years after transplantation was 28%. Chronic GVHD was fatal in 29 patients. Multivariate analysis demonstrated that development of chronic GVHD was favorably associated with both overall survival and event-free survival. Multivariate analysis identified risk factors of chronic GVHD: higher patient body weight, higher number of mismatched antigens for GVHD direction, myeloablative preparative regimen, use of mycophenolate mofetil in GVHD prophylaxis, and development of grades II to IV acute GVHD. Although chronic GVHD is a significant problem after CBT, it is associated with improved survival, perhaps due to graft-versus-malignancy effects. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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