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Blood, 1 October 2008, Vol. 112, No. 7, pp. 2617-2626. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Alter, H. J. Articles by Klein, H. G. Search for Related Content PubMed Articles by Alter, H. J. Articles by Klein, H. G. Related Collections Immunobiology Red Cells Transfusion Medicine Free Research Articles ASH 50th Anniversary Reviews Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  ASH 50TH ANNIVERSARY REVIEW The hazards of blood transfusion in historical perspective Harvey J. Alter1,*, and Harvey G. Klein1,* 1 Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD The beginning of the modern era of blood transfusion coincided with World War II and the resultant need for massive blood replacement. Soon thereafter, the hazards of transfusion, particularly hepatitis and hemolytic transfusion reactions, became increasingly evident. The past half century has seen the near eradication of transfusion-associated hepatitis as well as the emergence of multiple new pathogens, most notably HIV. Specific donor screening assays and other interventions have minimized, but not eliminated, infectious disease transmission. Other transfusion hazards persist, including human error resulting in the inadvertent transfusion of incompatible blood, acute and delayed transfusion reactions, transfusion-related acute lung injury (TRALI), transfusion-associated graft-versus-host disease (TA-GVHD), and transfusion-induced immunomodulation. These infectious and noninfectious hazards are reviewed briefly in the context of their historical evolution. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. J. Stotler, B. Eghtesad, E. Hsi, and B. Silver Rapid resolution of GVHD after orthotopic liver transplantation in a patient treated with alefacept Blood, May 21, 2009; 113(21): 5365 - 5366. [Full Text] [PDF] J. S. Bennett UV-C irradiation gives platelets a sunburn Blood, December 15, 2008; 112(13): 4784 - 4785. [Full Text] [PDF]

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