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Blood, 1 October 2008, Vol. 112, No. 7, pp. 2858-2868. Prepublished online as a Blood First Edition Paper on June 10, 2008; DOI 10.1182/blood-2008-03-145946. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-03-145946v1 112/7/2858    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jiang, Q. Articles by Su, L. Search for Related Content PubMed PubMed Citation Articles by Jiang, Q. Articles by Su, L. Related Collections Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2–/–C–/– mice in vivo Qi Jiang1,2,*, Liguo Zhang1,2,*, Rui Wang3, Jerry Jeffrey1,4, Michael L. Washburn1,4, Dedeke Brouwer1, Selena Barbour1, Grigoriy I. Kovalev1, Derya Unutmaz3, and Lishan Su1,2,4 1 Lineberger Comprehensive Cancer Center and 2 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill; 3 Department of Microbiology, New York University School of Medicine, New York; and 4 Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel Hill The role of FoxP3+CD4+ regulatory T (Treg) cells in HIV-1 disease in vivo is poorly understood due to the lack of a robust model. We report here that CD4+FoxP3+ T cells are developed in all lymphoid organs in humanized Rag2–/–C–/– (DKO-hu HSC) mice and they display both Treg phenotype and Treg function. These FoxP3+ Treg cells are preferentially infected and depleted by a pathogenic HIV-1 isolate in HIV-infected DKO-hu HSC mice; and depletion of Treg cells is correlated with induction of their apoptosis in vivo. When CD4+CD25+/hi Treg cells are depleted with the IL-2–toxin fusion protein (denileukin diftitox), HIV-1 infection is significantly impaired. This is demonstrated by reduced levels of productively infected cells in lymphoid organs and lower plasma viremia. Therefore, FoxP3+ Treg cells are productively infected and play an important role in acute HIV-1 infection in vivo. The DKO-hu HSC mouse will be a valuable model to study human Treg functions and their role in HIV-1 pathogenesis in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Acute HIV-1 infection: targeting the regulator Gregg Dean Blood 2008 112: 2600. [Full Text] [PDF] This article has been cited by other articles: M. E. Moreno-Fernandez, W. Zapata, J. T. Blackard, G. Franchini, and C. A. Chougnet Human Regulatory T Cells Are Targets for Human Immunodeficiency Virus (HIV) Infection, and Their Susceptibility Differs Depending on the HIV Type 1 Strain J. Virol., December 15, 2009; 83(24): 12925 - 12933. [Abstract] [Full Text] [PDF] D. M. Brainard, E. Seung, N. Frahm, A. Cariappa, C. C. Bailey, W. K. Hart, H.-S. Shin, S. F. Brooks, H. L. Knight, Q. Eichbaum, et al. Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice J. Virol., July 15, 2009; 83(14): 7305 - 7321. [Abstract] [Full Text] [PDF]

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