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Blood, 1 October 2008, Vol. 112, No. 7, pp. 2990-2995. Prepublished online as a Blood First Edition Paper on May 20, 2008; DOI 10.1182/blood-2008-01-135285. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-01-135285v1 112/7/2990    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stern, M. Articles by Velardi, A. Search for Related Content PubMed PubMed Citation Articles by Stern, M. Articles by Velardi, A. Related Collections Transplantation Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents TRANSPLANTATION Survival after T cell–depleted haploidentical stem cell transplantation is improved using the mother as donor Martin Stern1, Loredana Ruggeri2, Antonella Mancusi2, Maria Ester Bernardo3, Claudia de Angelis2, Christoph Bucher4, Franco Locatelli3, Franco Aversa2, and Andrea Velardi2 1 Department of Hematology, University Hospital Basel, Basel, Switzerland; 2 Division of Hematology and Clinical Immunology, Department of Clinical Medicine, University of Perugia, Perugia, Italy; 3 Oncoematologia Pediatrica, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Università di Pavia, Pavia, Italy; and 4 Department of Pediatrics, Division of Hematology-Oncology, Blood and Marrow Transplantation, University of Minnesota, Minneapolis We hypothesized that transplacental leukocyte trafficking during pregnancy, which induces long-term, stable, reciprocal microchimerism in mother and child, might influence outcome of patients with acute leukemia given parental donor haploidentical hematopoietic stem cell transplantation (HSCT). We analyzed the outcome of 118 patients who received transplants for acute leukemia in 2 centers. Patients received highly T cell–depleted haploidentical grafts after myelo-ablative conditioning. Five-year event-free survival was better in patients who received transplants from the mother than from the father (50.6% ± 7.6% vs 11.1% ± 4.2%; P < .001). Better survival was the result of both reduced incidence of relapse and transplantation-related mortality. The protective effect was seen in both female and male recipients, in both lymphoid and myeloid diseases; it was more evident in patients receiving transplants in remission than in chemotherapy-resistant relapse. Incidences of rejection and acute graft-versus-host disease were not significantly influenced. Multivariate analysis confirmed donor sex in parental donor transplantation as an independent prognostic factor for survival (hazard ratio, father vs mother = 2.36; P = .003). In contrast, in a control cohort of patients who received transplants from haploidentical siblings, donor sex had no influence on outcome. Although obtained in a retrospective analysis, these data suggest that the mother of the patient should be preferred as donor for haploidentical HSCT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Mother and child reunion Jan J. Cornelissen Blood 2008 112: 2604-2605. [Full Text] [PDF]

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