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Blood, 15 October 2008, Vol. 112, No. 8, pp. 3293-3302. Prepublished online as a Blood First Edition Paper on July 17, 2008; DOI 10.1182/blood-2008-02-138040. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-02-138040v1 112/8/3293    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Palendira, U. Articles by Moss, P. Search for Related Content PubMed PubMed Citation Articles by Palendira, U. Articles by Moss, P. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow Umaimainthan Palendira1,2,*, Rosanna Chinn1,*, Wajid Raza1, Karen Piper1, Guy Pratt1, Lee Machado1, Andrew Bell1, Naeem Khan1, Andrew D. Hislop1, Richard Steyn3, Alan B. Rickinson1, Christopher D. Buckley4, and Paul Moss1 1 Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom; 2 Garvan Institute for Medical Research, Sydney, Australia; 3 Heartlands Hospital, Birmingham, United Kingdom; and 4 Medical Research Council (MRC) Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom The bone marrow plays a unique role within the immune system. We compared the phenotype and function of virus-specific CD8+ T cells from matched samples of human peripheral blood and bone marrow. Analysis of virus-specific memory CD8+ T cells showed widely divergent partition of antigen-specific populations between blood and bone marrow. T cells specific for Epstein-Barr virus (EBV) lytic antigens were enriched 3-fold in marrow compared with blood, whereas the response to EBV latent epitopes was equivalent between the 2 compartments. No difference in EBV viral load or expression of the EBV lytic protein was observed between blood and bone marrow. In direct contrast, although cytomegalo-virus (CMV)–specific T cells were the largest virus-specific population within peripheral blood, they were reduced by 60% within marrow. Bone marrow T cells were found to exhibit a unique CCR5+CXCR6+CXCR3– homing phenotype which has not been observed on T cells from other secondary lymphoid organs or peripheral organs. Expression of CCR5 and CXCR6 was higher on EBV-specific T cells within peripheral blood compared with CMV-specific populations. These observations identify a novel bone marrow homing phenotype for CD8+ memory T cells, which necessitates a reevaluation of the magnitude of antigen-specific populations within the lymphoid system. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M P Pender, P A Csurhes, A Lenarczyk, C M M Pfluger, and S R Burrows Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, May 1, 2009; 80(5): 498 - 505. [Abstract] [Full Text] [PDF] J. J. Melenhorst, P. Scheinberg, P. K. Chattopadhyay, E. Gostick, K. Ladell, M. Roederer, N. F. Hensel, D. C. Douek, A. J. Barrett, and D. A. Price High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow Blood, March 5, 2009; 113(10): 2238 - 2244. [Abstract] [Full Text] [PDF]

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