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Blood, 1 November 2008, Vol. 112, No. 9, pp. 3543-3553. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Weissman, I. L. Articles by Shizuru, J. A. Search for Related Content PubMed PubMed Citation Articles by Weissman, I. L. Articles by Shizuru, J. A. Related Collections Hematopoiesis and Stem Cells Free Research Articles ASH 50th Anniversary Reviews Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  ASH 50TH ANNIVERSARY REVIEW The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases Irving L. Weissman1,2,3,4, and Judith A. Shizuru5 1 Stanford Institute of Stem Cell Biology and Regenerative Medicine 2 Ludwig Center for Cancer Stem Cell Research and Medicine, Departments of3 Pathology and 4 Developmental Biology, and 5 Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University Medical Center, Stanford, CA Advances in the understanding of the cells of the hematopoietic system have provided a rich basis for improving clinical hematopoietic cell transplants; finding and using proteins and molecules to amplify or suppress particular blood cell types; understanding the stepwise progression of preleukemic stages leading first to chronic myeloid disorders, then the emergence of acute blastic leukemias; and treating malignant and nonmalignant diseases with cell subsets. As a result of intense scientific investigation, hematopoietic stem cells (HSCs) have been isolated and their key functional characteristics revealed—self-renewal and multilineage differentiation. These characteristics are now found to be present in all tissue/organ stem cell studies, and even in the analysis of pluripotent embryonic, nuclear transfer, and induced pluripotent stem cells. Studies on HSC have identified hematopoiesis as one of the best systems for studying developmental cell lineages and as the best for understanding molecular changes in cell fate decision-making and for finding preclinical and clinical platforms for tissue and organ replacement, regeneration, and oncogenesis. Here we review the steps, from our viewpoint, that led to HSC isolation and its importance in self-nonself immune recognition. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. M. Cao, A. Thomas, Y. Wang, S. Tsai, K. Logronio, and J. A. Shizuru A chromosome 16 quantitative trait locus regulates allogeneic bone marrow engraftment in nonmyeloablated mice Blood, July 2, 2009; 114(1): 202 - 210. [Abstract] [Full Text] [PDF]

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