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Blood, 1 November 2008, Vol. 112, No. 9, pp. 3582-3586. Prepublished online as a Blood First Edition Paper on June 17, 2008; DOI 10.1182/blood-2008-04-151076. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-04-151076v1 112/9/3582    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kristinsson, S. Y. Articles by Landgren, O. Search for Related Content PubMed PubMed Citation Articles by Kristinsson, S. Y. Articles by Landgren, O. Related Collections Hemostasis, Thrombosis, and Vascular Biology Neoplasia Free Research Articles Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Deep vein thrombosis after monoclonal gammopathy of undetermined significance and multiple myeloma Sigurdur Y. Kristinsson1, Thomas R. Fears2, Gloria Gridley2, Ingemar Turesson3, Ulf-Henrik Mellqvist4, Magnus Björkholm1, and Ola Landgren2 1 Department of Medicine, Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden; 2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD; 3 Section of Hematology, Department of Medicine, Malmö University Hospital, University of Lund, Malmö, Sweden; and 4 Department of Medicine, Section of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden Patients with multiple myeloma (MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, 2 small hospital-based studies observed persons with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4 196 197 veterans hospitalized at least once at US Veterans Affairs hospitals, we identified a total of 2374 cases of MGUS, and 39 272 persons were diagnosed with DVT (crude incidence 0.9 per 1000 person-years). A total of 31 and 151 DVTs occurred among MGUS and MM patients, respectively (crude incidence 3.1 and 8.7 per 1000 person-years, respectively; P < .01). Compared with the entire study population, the relative risk (RR) of DVT after a diagnosis of MGUS and MM was 3.3 (95% confidence interval [CI], 2.3-4.7) and 9.2 (95% CI, 7.9-10.8), respectively. The most prominent excess risk of DVT was found during the first year after diagnosis of MGUS (RR = 8.4; 95% CI, 5.7-12.2) and MM (RR = 11.6; 95% CI, 9.2-14.5). Among 229 MGUS cases (9.5%) that progressed to MM, only one person had a DVT diagnosis before transformation. Our findings suggest the operation of shared underlying mechanisms causing coagulation abnormalities among patients with MGUS and MM. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: MGUS: not so benign after all Michael J. Kovacs Blood 2008 112: 3533. [Full Text] [PDF]

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