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Blood, 19 March 2009, Vol. 113, No. 12, pp. 2629-2636. Prepublished online as a Blood First Edition Paper on December 15, 2008; DOI 10.1182/blood-2008-06-164806. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-06-164806v1 113/12/2629    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Asano, N. Articles by Nakamura, S. Search for Related Content PubMed PubMed Citation Articles by Asano, N. Articles by Nakamura, S. Related Collections Free Research Articles Lymphoid Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients Naoko Asano13, Kazuhito Yamamoto4, Jun-Ichi Tamaru5, Takashi Oyama6, Fumihiro Ishida7, Koichi Ohshima8, Tadashi Yoshino9, Naoya Nakamura10, Shigeo Mori11, Osamu Yoshie12, Yoshie Shimoyama1, Yasuo Morishima4, Tomohiro Kinoshita13, and Shigeo Nakamura1 1 Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya; 2 Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto; 3 Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya; 4 Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya; 5 Department of Pathology, Saitama Medical Center, Saitama Medical School, Kawagoe; 6 Department of Hematology, Nagoya 2nd Red Cross Hospital, Nagoya; 7 Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto; 8 Department of Pathology, School of Medicine, Kurume University, Kurume; 9 Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama; 10 Department of Pathology, Tokai University School of Medicine, Isehara; 11 Department of Pathology, Teikyo University School of Medicine, Tokyo; 12 Department of Microbiology, Kinki University School of Medicine, Osaka; and 13 Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan Age-related Epstein-Barr virus–associated B-cell lymphoproliferative disorder (aEBVLPD) is a disease group characterized by EBV-associated large B-cell lymphoma in elderly without predisposing immunodeficiency. In nearly one- third of cases, aEBVLPD occurs as a polymorphous subtype with reactive cell-rich components, bearing a morphologic similarity to classic Hodgkin lymphoma (cHL). The aim of this study was to clarify clinicopathologic differences between the polymorphic subtype of aEBVLPD (n = 34) and EBV+ cHL (n = 108) in patients aged 50 years or older. Results showed that aEBVLPD was more closely associated with aggressive clinical parameters than cHL, with a higher age at onset (71 vs 63 years); lower male predominance (male-female ratio, 1.4 vs 3.3); and a higher rate of involvement of the skin (18% vs 2%), gastrointestinal tract (15% vs 4%), and lung (12% vs 2%). aEBVLPD was histopathologically characterized by a higher ratio of geographic necrosis, greater increase (> 30%) in cytotoxic T cells among background lymphocytes, higher positivity for CD20 and EBNA2, and absence of CD15 expression. As predicted by the clinical profile, aEBVLPD had a significantly poorer prognosis than EBV+ cHL (P < .001). The polymorphous subtype of aEBVLPD constitutes an aggressive group with an immune response distinct from EBV+ cHL, and requires the development of innovative therapeutic strategies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. I. Cohen, H. Kimura, S. Nakamura, Y.-H. Ko, and E. S. Jaffe Epstein-Barr virus-associated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8-9 September 2008 Ann. Onc., September 1, 2009; 20(9): 1472 - 1482. [Abstract] [Full Text] [PDF]

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