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Blood, 9 April 2009, Vol. 113, No. 15, pp. 3553-3557. Prepublished online as a Blood First Edition Paper on February 6, 2009; DOI 10.1182/blood-2008-08-174839. This Article Full Text Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: blood-2008-08-174839v1 113/15/3553    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Carlotti, E. Articles by Fitzgibbon, J. Search for Related Content PubMed PubMed Citation Articles by Carlotti, E. Articles by Fitzgibbon, J. Related Collections Lymphoid Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  LYMPHOID NEOPLASIA Brief Report Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone Emanuela Carlotti1, David Wrench1, Janet Matthews1, Sameena Iqbal1, Andrew Davies1, Andrew Norton1, Jason Hart2, Raymond Lai3, Silvia Montoto1, John G. Gribben1, T. Andrew Lister1, and Jude Fitzgibbon1 1 Centre for Medical Oncology Laboratory, Barts and The London School of Medicine and Dentistry, London, United Kingdom; 2 Department of Medicine, University of Alberta and Cross Cancer Institute, Edmonton, AB; and 3 Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB To investigate the cell of origin linking follicular (FL) and transformed (t-FL) lymphomas, we analyzed the somatic hypermutation (SHM) pattern of the variable region of the immunoglobulin heavy gene (IgH-VH) in 18 sequential FL/t-FL samples and a father (donor) and son (recipient), who developed FL and t-FL, after transplantation. Genealogic trees showed a pattern compatible with a common progenitor cell (CPC) origin in 13 cases. The identification of the t-FL clonotype in the previous FL sample and of the putative CPC sequence in both the FL/t-FL biopsies showed that the intraclonal diversity of FL and t-FL germinal centers (GCs) is more intricate than previously described, and all 3 clonotypes (CPC, FL, t-FL) may occur simultaneously within the same lymph node. On the basis of the father/son model, this CPC must be long-lived, providing a possible explanation for the incurable nature of this disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Carlotti and J. G. Gribben Stem cell mimicry: key to transformation? Blood, October 8, 2009; 114(15): 3133 - 3134. [Abstract] [Full Text] [PDF] A. J. Gentles, A. A. Alizadeh, S.-I. Lee, J. H. Myklebust, C. M. Shachaf, B. Shahbaba, R. Levy, D. Koller, and S. K. Plevritis A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients Blood, October 8, 2009; 114(15): 3158 - 3166. [Abstract] [Full Text] [PDF] J. Agopian, J.-M. Navarro, A.-C. Gac, Y. Lecluse, M. Briand, P. Grenot, P. Gauduchon, P. Ruminy, P. Lebailly, B. Nadel, et al. Agricultural pesticide exposure and the molecular connection to lymphomagenesis J. Exp. Med., July 6, 2009; 206(7): 1473 - 1483. [Abstract] [Full Text] [PDF]

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