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Blood, 16 April 2009, Vol. 113, No. 16, pp. 3679-3681. Prepublished online as a Blood First Edition Paper on February 20, 2009; DOI 10.1182/blood-2008-10-184705. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-10-184705v1 113/16/3679    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by De Bruin, M. L. Articles by van Leeuwen, F. E. Search for Related Content PubMed PubMed Citation Articles by De Bruin, M. L. Articles by van Leeuwen, F. E. Related Collections Lymphoid Neoplasia Brief Reports Clinical Trials and Observations Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Brief report Malignant mesothelioma after radiation treatment for Hodgkin lymphoma Marie L. De Bruin1,*, Jacobus A. Burgers2,*, Paul Baas2, Mars B. van 't Veer3, Evert M. Noordijk4, Marieke W. J. Louwman5, Josée M. Zijlstra6, Hendrik van den Berg7, Berthe M. P. Aleman8, and Flora E. van Leeuwen1 Departments of 1 Epidemiology and 2 Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam; 3 Department of Hematology, Erasmus MC, Daniel den Hoed Cancer Center, Rotterdam; 4 Department of Radiotherapy, Leiden University Medical Center, Leiden; 5 Eindhoven Cancer Registry, Comprehensive Cancer Center South, Eindhoven; 6 Department of Hematology, Free University Medical Center, Amsterdam; 7 Department of Paediatric Oncology, Emma Children's Hospital/Academic Medical Center, University of Amsterdam, Amsterdam; and 8 Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands Malignant mesothelioma is a relatively uncommon malignancy. Although the pathogenesis is primarily related to asbestos, the disease may be associated with radiation exposure. Recently, increased risks for second primary mesothelioma after radiation for lymphoma have been reported. Because these findings are based on small numbers of patients, they need to be confirmed. We examined mesothelioma risk in 2567 5-year survivors of Hodgkin lymphoma. The risk was almost 30-fold increased in Hodgkin lymphoma patients treated with irradiation compared with the general population. Although histology and survival of the mesothelioma cases were comparable with cases from the general population, asbestos exposure and the proportion of males were lower than expected. The evidence for radiotherapy as cause for mesothelioma independent of exposure to asbestos is expanding, and the diagnosis of mesothelioma should be kept in mind whenever related symptoms arise in patients who had previous irradiation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Consistency and synergy M. Jane Teta and Meghan E. Wagner Blood 2009 114: 2000-2001. [Full Text] [PDF] Response:Malignant mesothelioma after irradiation: consistency and synergy Jacobus A. Burgers, Marieke L. De Bruin, Paul Baas, and Floor van Leeuwen Blood 2009 114: 2001. [Full Text] [PDF] This article has been cited by other articles: M. J. Teta and M. E. Wagner Consistency and synergy Blood, August 27, 2009; 114(9): 2000 - 2001. [Full Text] [PDF] J. A. Burgers, M. L. De Bruin, P. Baas, and F. van Leeuwen Response:Malignant mesothelioma after irradiation: consistency and synergy Blood, August 27, 2009; 114(9): 2001 - 2001. [Full Text] [PDF]

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