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Blood, 23 April 2009, Vol. 113, No. 17, pp. 3911-3917. Prepublished online as a Blood First Edition Paper on December 16, 2008; DOI 10.1182/blood-2008-08-175745. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-08-175745v1 113/17/3911    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ku, G. H. Articles by Wun, T. Search for Related Content PubMed PubMed Citation Articles by Ku, G. H. Articles by Wun, T. Related Collections Genomics Free Research Articles Myeloid Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival Grace H. Ku1, Richard H. White2, Helen K. Chew3,4, Danielle J. Harvey5, Hong Zhou2, and Ted Wun3,4,6,7 1 Division of Hematology and Oncology, School of Medicine, University of California San Diego; 2 Division of General Internal Medicine and 3 Division of Hematology and Oncology, School of Medicine, University of California Davis, Sacramento; 4 Section of Hematology and Oncology, Veterans Affairs Northern California Health Care System, Sacramento; and 5 Division of Biostatistics, Department of Public Health Sciences, School of Medicine, and 6 Department of Pathology and Laboratory Medicine, School of Medicine, and 7 Clinical and Translational Sciences Center, University of California Davis, Sacramento A population-based cohort was used to determine the incidence and risk factors associated with development of venous thromboembolism (VTE) among Californians diagnosed with acute leukemia between 1993 to 1999. Principal outcomes were deep vein thrombosis in both the lower and upper extremities, pulmonary embolism, and mortality. Among 5394 cases with acute myelogenous leukemia (AML), the 2-year cumulative incidence of VTE was 281 (5.2%). Sixty-four percent of the VTE events occurred within 3 months of AML diagnosis. In AML patients, female sex, older age, number of chronic comorbidities, and presence of a catheter were significant predictors of development of VTE within 1 year. A diagnosis of VTE was not associated with reduced survival in AML patients. Among 2482 cases with acute lymphoblastic leukemia (ALL), the 2-year incidence of VTE in ALL was 4.5%. Risk factors for VTE were presence of a central venous catheter, older age, and number of chronic comorbidities. In the patients with ALL, development of VTE was associated with a 40% increase in the risk of dying within 1 year. The incidence of VTE in acute leukemia is appreciable, and is comparable with the incidence in many solid tumors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Falanga and M. Marchetti Venous Thromboembolism in the Hematologic Malignancies J. Clin. Oncol., October 10, 2009; 27(29): 4848 - 4857. [Abstract] [Full Text] [PDF] O. Sanchez, B. Planquette, and G. Meyer Update on acute pulmonary embolism Eur. Respir. Rev., September 1, 2009; 18(113): 137 - 147. [Full Text] [PDF] Venous Thromboembolism in Patients with Acute Leukemia Journal Watch Oncology and Hematology, May 12, 2009; 2009(512): 1 - 1. [Full Text]

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