SEARCH:   Advanced

Blood, 23 April 2009, Vol. 113, No. 17, pp. 3931-3937. Prepublished online as a Blood First Edition Paper on November 24, 2008; DOI 10.1182/blood-2008-10-185256. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2008-10-185256v1 113/17/3931    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Au, W.-y. Articles by Liang, R. Search for Related Content PubMed PubMed Citation Articles by Au, W.-y. Articles by Liang, R. Related Collections Free Research Articles Lymphoid Neoplasia Clinical Trials and Observations Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project Wing-yan Au1, Dennis D. Weisenburger2, Tanin Intragumtornchai3, Shigeo Nakamura4, Won-Seog Kim5, Ivy Sng6, Julie Vose2, James O. Armitage2, Raymond Liang1, and for the International Peripheral T-Cell Lymphoma Project 1 Department of Medicine, Queen Mary Hospital, Hong Kong, China; 2 Departments of Internal Medicine and Pathology and Microbiology, University of Nebraska Medical Center, Omaha; 3 Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 4 Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan; 5 Division of Haemato-Oncology, Department of Medicine, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, Korea; and 6 Department of Pathology, Singapore General Hospital, Singapore Among 1153 new adult cases of peripheral/T-cell lymphoma from 1990-2002 at 22 centers in 13 countries, 136 cases (11.8%) of extranodal natural killer (NK)/T-cell lymphoma were identified (nasal 68%, extranasal 26%, aggressive/unclassifiable 6%). The disease frequency was higher in Asian than in Western countries and in Continental Asia than in Japan. There were no differences in age, sex, ethnicity, or immunophenotypic profile between the nasal and extranasal cases, but the latter had more adverse clinical features. The median overall survival (OS) was better in nasal compared with the extranasal cases in early- (2.96 vs 0.36 years, P < .001) and late-stage disease (0.8 vs 0.28 years, P = .031). The addition of radiotherapy for early-stage nasal cases yielded survival benefit (P = .045). Among nasal cases, both the International Prognostic Index (P = .006) and Korean NK/T-cell Prognostic Index (P < .001) were prognostic. In addition, Ki67 proliferation greater than 50%, transformed tumor cells greater than 40%, elevated C-reactive protein level (CRP), anemia (< 11 g/dL) and thrombocytopenia (< 150 x 109/L) predicts poorer OS for nasal disease. No histologic or clinical feature was predictive in extranasal disease. We conclude that the clinical features and treatment response of extranasal NK/T-cell lymphoma are different from of those of nasal lymphoma. However, the underlying features responsible for these differences remain to be defined. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Differences between nasal and extranasal NK/T-cell lymphoma Ritsuro Suzuki, Junji Suzumiya, and Kazuo Oshimi Blood 2009 113: 6260-6261. [Full Text] [PDF] Response: Prognosis of stage I/II nonnasal extranodal NK/T cell lymphoma Wing-yan Au, Dennis D Weisenburger, Raymond Liang, and for the International Peripheral T-cell Lymphoma Project Blood 2009 113: 6261-6262. [Full Text] [PDF] This article has been cited by other articles: Z.-Y. Wang, Y.-X. Li, W.-H. Wang, J. Jin, H. Wang, Y.-W. Song, Q.-F. Liu, S.-L. Wang, Y.-P. Liu, S.-N. Qi, et al. Primary radiotherapy showed favorable outcome in treating extranodal nasal-type NK/T-cell lymphoma in children and adolescents Blood, November 26, 2009; 114(23): 4771 - 4776. [Abstract] [Full Text] [PDF] M. Yamaguchi, K. Tobinai, M. Oguchi, N. Ishizuka, Y. Kobayashi, Y. Isobe, K. Ishizawa, N. Maseki, K. Itoh, N. Usui, et al. Phase I/II Study of Concurrent Chemoradiotherapy for Localized Nasal Natural Killer/T-Cell Lymphoma: Japan Clinical Oncology Group Study JCOG0211 J. Clin. Oncol., November 20, 2009; 27(33): 5594 - 5600. [Abstract] [Full Text] [PDF] R. Suzuki, J. Suzumiya, M. Yamaguchi, S. Nakamura, J. Kameoka, H. Kojima, M. Abe, T. Kinoshita, T. Yoshino, K. Iwatsuki, et al. Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type Ann. Onc., October 22, 2009; (2009) mdp418v1. [Abstract] [Full Text] [PDF] W.-y. Au, D. D Weisenburger, R. Liang, and for the International Peripheral T-cell Lymphoma P Response: Prognosis of stage I/II nonnasal extranodal NK/T cell lymphoma Blood, June 11, 2009; 113(24): 6261 - 6262. [Full Text] [PDF] R. Suzuki, J. Suzumiya, and K. Oshimi Differences between nasal and extranasal NK/T-cell lymphoma Blood, June 11, 2009; 113(24): 6260 - 6261. [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020