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Blood, 23 April 2009, Vol. 113, No. 17, pp. 4008-4010. Prepublished online as a Blood First Edition Paper on February 24, 2009; DOI 10.1182/blood-2008-12-192443. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2008-12-192443v1 113/17/4008    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hughes, T. Articles by Caligiuri, M. A. Search for Related Content PubMed PubMed Citation Articles by Hughes, T. Articles by Caligiuri, M. A. Related Collections Immunobiology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief Report Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22 Tiffany Hughes1, Brian Becknell2, Susan McClory1,3, Edward Briercheck1,3, Aharon G. Freud4, Xiaoli Zhang5, Hsiaoyin Mao6, Gerard Nuovo6, Jianhua Yu6, and Michael A. Caligiuri6 1 Integrated Biomedical Graduate Program; 2 Department of Pediatrics, and 3 Medical Scientist Program, The Ohio State University College of Medicine, Columbus; 4 Department of Pathology, Stanford University School of Medicine, CA; and 5 Center for Biostatistics and 6 Department of Internal Medicine, Division of Hematology/Oncology, Department of Microbiology, Immunology, Virology and Medical Genetics, The Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute at The Ohio State University, Columbus Considerable functional heterogeneity within human natural killer (NK) cells has been revealed through the characterization of distinct NK-cell subsets. Accordingly, a small subset of CD56+NKp44+NK cells, termed NK-22 cells, was recently described within secondary lymphoid tissue (SLT) as IL-22– when resting, with a minor fraction of this population becoming IL-22+ when activated. Here we discover that the vast majority of stage 3 immature NK (iNK) cells in SLT constitutively and selectively express IL-22, a TH17 cytokine important for mucosal immunity, whereas earlier and later stages of NK developmental intermediates do not express IL-22. These iNK cells have a surface phenotype of CD34–CD117+CD161+CD94–, largely lack expression of NKp44 and CD56, and do not produce IFN- or possess cytolytic activity. In summary, stage 3 iNK cells are highly enriched for IL-22 and IL-26 messenger RNA, and IL-22 protein production, but do not express IL-17A or IL-17F. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Dhiman, M. Indramohan, P. F. Barnes, R. C. Nayak, P. Paidipally, L. V. M. Rao, and R. Vankayalapati IL-22 Produced by Human NK Cells Inhibits Growth of Mycobacterium tuberculosis by Enhancing Phagolysosomal Fusion J. Immunol., November 15, 2009; 183(10): 6639 - 6645. [Abstract] [Full Text] [PDF] E. Volpe, M. Touzot, N. Servant, M.-A. Marloie-Provost, P. Hupe, E. Barillot, and V. Soumelis Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production Blood, October 22, 2009; 114(17): 3610 - 3614. [Abstract] [Full Text] [PDF]

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