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 Blood, 8 January 2009, Vol. 113, No. 2, pp. 291-298.
Prepublished online as a Blood First Edition Paper on August 14, 2008; DOI 10.1182/blood-2008-04-153239.

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REVIEW ARTICLE

A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects

Bas J. Wouters1, Bob Löwenberg1, and Ruud Delwel1

1 Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands

The past decade has shown a marked increase in the use of high-throughput assays in clinical research into human cancer, including acute myeloid leukemia (AML). In particular, genome-wide gene expression profiling (GEP) using DNA microarrays has been extensively used for improved understanding of the diagnosis, prognosis, and pathobiology of this heterogeneous disease. This review discusses the progress that has been made, places the technologic limitations in perspective, and highlights promising future avenues


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Home page
 Brief Funct Genomic ProteomicHome page
U. Bacher, A. Kohlmann, and T. Haferlach
Perspectives of gene expression profiling for diagnosis and therapy in haematological malignancies
Brief Funct Genomic Proteomic, May 27, 2009; (2009) elp011v1.
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