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Blood, 8 January 2009, Vol. 113, No. 2, pp. 358-369. Prepublished online as a Blood First Edition Paper on October 15, 2008; DOI 10.1182/blood-2008-03-145615. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-03-145615v1 113/2/358    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kuttruff, S. Articles by Steinle, A. Search for Related Content PubMed PubMed Citation Articles by Kuttruff, S. Articles by Steinle, A. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY NKp80 defines and stimulates a reactive subset of CD8 T cells Sabrina Kuttruff1, Sven Koch2, Alexandra Kelp1, Graham Pawelec2, Hans-Georg Rammensee1, and Alexander Steinle1 1 Department of Immunology, Institute for Cell Biology, Eberhard-Karls-University Tübingen; and 2 Center for Medical Research (ZMF), University of Tübingen, Tübingen, Germany NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK) cells and stimulates their cytotoxicity and cytokine release. Recently, we demonstrated that the ligand for NKp80 is the myeloid-specific CTLR activation-induced C-type lectin (AICL), which is encoded in the natural killer gene complex (NKC) adjacent to NKp80. Here, we show that NKp80 also is expressed on a minor fraction of human CD8 T cells that exhibit a high responsiveness and an effector memory phenotype. Gene expression profiling and flow cytometric analyses revealed that this NKp80+ T-cell subset is characterized by the coexpression of other NK receptors and increased levels of cytotoxic effector molecules and adhesion molecules mediating access to sites of inflammation. NKp80 ligation augmented CD3-stimulated degranulation and interferon (IFN) secretion by effector memory T cells. Furthermore, engagement of NKp80 by AICL-expressing transfectants or macrophages markedly enhanced CD8 T-cell responses in alloreactive settings. Collectively, our data demonstrate that NKp80 is expressed on a highly responsive subset of effector memory CD8 T cells with an inflammatory NK-like phenotype and promotes T-cell responses toward AICL-expressing cells. Hence, NKp80 may enable effector memory CD8 T cells to interact functionally with cells of myeloid origin at sites of inflammation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. Thebault, N. Lhermite, G. Tilly, L. Le Texier, T. Quillard, M. Heslan, I. Anegon, J.-P. Soulillou, S. Brouard, B. Charreau, et al. The C-Type Lectin-Like Receptor CLEC-1, Expressed by Myeloid Cells and Endothelial Cells, Is Up-Regulated by Immunoregulatory Mediators and Moderates T Cell Activation J. Immunol., September 1, 2009; 183(5): 3099 - 3108. [Abstract] [Full Text] [PDF]

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