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 Blood, 14 May 2009, Vol. 113, No. 20, pp. 4942-4954.
Prepublished online as a Blood First Edition Paper on February 25, 2009; DOI 10.1182/blood-2008-08-174318.

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PLATELETS AND THROMBOPOIESIS

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

Yotis A. Senis1,*, Michael G. Tomlinson1,*, Stuart Ellison1, Alexandra Mazharian1, Jenson Lim1, Yan Zhao1, Kristin N. Kornerup1, Jocelyn M. Auger1, Steve G. Thomas1, Tarvinder Dhanjal1, Neena Kalia1, Jing W. Zhu2, Arthur Weiss2, and Steve P. Watson1

1 Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; and 2 Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco

Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke. Platelet adhesion, activation, and aggregation at sites of vascular injury are regulated by a diverse repertoire of tyrosine kinase–linked and G protein–coupled receptors. Src family kinases (SFKs) play a central role in initiating and propagating signaling from several platelet surface receptors; however, the underlying mechanism of how SFK activity is regulated in platelets remains unclear. CD148 is the only receptor-like protein tyrosine phosphatase identified in platelets to date. In the present study, we show that mutant mice lacking CD148 exhibited a bleeding tendency and defective arterial thrombosis. Basal SFK activity was found to be markedly reduced in CD148-deficient platelets, resulting in a global hyporesponsiveness to agonists that signal through SFKs, including collagen and fibrinogen. G protein–coupled receptor responses to thrombin and other agonists were also marginally reduced. These results highlight CD148 as a global regulator of platelet activation and a novel antithrombotic drug target.


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