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Blood, 21 May 2009, Vol. 113, No. 21, pp. 5041-5048. Prepublished online as a Blood First Edition Paper on September 22, 2008; DOI 10.1182/blood-2008-07-171678. This Article Full Text Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: blood-2008-07-171678v1 113/21/5041    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Kamei, M. Articles by Akatsuka, Y. PubMed PubMed Citation Articles by Kamei, M. Articles by Akatsuka, Y. Related Collections Transplantation Plenary Papers Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PLENARY PAPER HapMap scanning of novel human minor histocompatibility antigens Michi Kamei1,2,*, Yasuhito Nannya35,*, Hiroki Torikai1, Takakazu Kawase1,6, Kenjiro Taura7, Yoshihiro Inamoto8, Taro Takahashi8, Makoto Yazaki9, Satoko Morishima1, Kunio Tsujimura10, Koichi Miyamura5,8, Tetsuya Ito2, Hajime Togari2, Stanley R. Riddell11, Yoshihisa Kodera5,8, Yasuo Morishima5,12, Toshitada Takahashi13, Kiyotaka Kuzushima1, Seishi Ogawa4,5,, and Yoshiki Akatsuka1,5, 1 Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan; 2 Department of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Science, Nagoya, Japan; 3 Department of Hematology/Oncology and 4 The 21st Century Center of Excellence (COE) Program, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; 5 Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan; 6 Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan; 7 Department of Information and Communication Engineering, Graduate School of Information Science, University of Tokyo, Tokyo, Japan; 8 Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan; 9 Department of Pediatrics, Higashi Municipal Hospital of Nagoya, Nagoya, Japan; 10 Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan; 11 Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 12 Department of Hematology and Cell Therapy, Aichi Cancer Center Central Hospital, Nagoya, Japan; and 13 Aichi Comprehensive Health Science Center, Aichi Health Promotion Foundation, Chita-gun, Japan Minor histocompatibility antigens (mHags) are molecular targets of allo-immunity associated with hematopoietic stem cell transplantation (HSCT) and involved in graft-versus-host disease, but they also have beneficial antitumor activity. mHags are typically defined by host SNPs that are not shared by the donor and are immunologically recognized by cytotoxic T cells isolated from post-HSCT patients. However, the number of molecularly identified mHags is still too small to allow prospective studies of their clinical importance in transplantation medicine, mostly due to the lack of an efficient method for isolation. Here we show that when combined with conventional immunologic assays, the large data set from the International HapMap Project can be directly used for genetic mapping of novel mHags. Based on the immunologically determined mHag status in HapMap panels, a target mHag locus can be uniquely mapped through whole genome association scanning taking advantage of the unprecedented resolution and power obtained with more than 3 000 000 markers. The feasibility of our approach could be supported by extensive simulations and further confirmed by actually isolating 2 novel mHags as well as 1 previously identified example. The HapMap data set represents an invaluable resource for investigating human variation, with obvious applications in genetic mapping of clinically relevant human traits. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Scanning for the origins of mHags John A. Hansen Blood 2009 113: 5040. [Full Text] [PDF] This article has been cited by other articles: A. N. Stumpf, E. D. van der Meijden, C. A. M. van Bergen, R. Willemze, J. H. F. Falkenburg, and M. Griffioen Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity Blood, October 22, 2009; 114(17): 3684 - 3692. [Abstract] [Full Text] [PDF] J. A. Hansen Scanning for the origins of mHags Blood, May 21, 2009; 113(21): 5040 - 5040. [Full Text] [PDF]

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