SEARCH:   Advanced

Blood, 21 May 2009, Vol. 113, No. 21, pp. 5237-5245. Prepublished online as a Blood First Edition Paper on January 14, 2009; DOI 10.1182/blood-2008-11-189407. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-11-189407v1 113/21/5237    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Stamatopoulos, B. Articles by Lagneaux, L. PubMed PubMed Citation Articles by Stamatopoulos, B. Articles by Lagneaux, L. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  LYMPHOID NEOPLASIA microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification Basile Stamatopoulos1, Nathalie Meuleman1, Benjamin Haibe-Kains2,3, Pascale Saussoy4, Eric Van Den Neste4, Lucienne Michaux4,5, Pierre Heimann6,7, Philippe Martiat1, Dominique Bron1, and Laurence Lagneaux1 1 Laboratory of Experimental Hematology, Faculty of Medicine, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels; 2 Functional Genomics and Translational Research Unit, Faculty of Medicine, Institut Jules Bordet, ULB, Brussels; 3 Machine Learning Group, Faculty of Sciences, ULB, Brussels; 4 Cliniques Universitaires Saint Luc, Service de Biologie Hématologique, Brussels; 5 Center for Human Genetics, KU Leuven, Leuven; 6 Department of Medical Genetics, Erasme Hospital, Faculty of Medicine, ULB, Brussels; and 7 Department of Cytogenetics, Institut Jules Bordet, ULB, Brussels, Belgium Aberrant expression of microRNAs has been recently associated with chronic lymphocytic leukemia (CLL) outcome. Although disease evolution can be predicted by several prognostic factors, a better outcome individualization in a given patient is still of utmost interest. Here, we showed that miR-29c and miR-223 expression levels decreased significantly with progression from Binet stage A to C were significantly lower in poor prognostic subgroups (defined by several prognostic factors) and could significantly predict treatment-free survival (TFS) and overall survival (OS). Furthermore, we developed a quantitative real-time polymerase chain reaction (qPCR) score combining miR-29c, miR-223, ZAP70, and LPL (from 0 to 4 poor prognostic markers) to stratify treatment and death risk in a cohort of 110 patients with a median follow-up of 72 months (range, 2-312). Patients with a score of 0/4, 1/4, 2/4, 3/4, and 4/4 had a median TFS of greater than 312, of 129, 80, 36, and 19 months, respectively (hazard ratio, HR0/4 < 1/4 < 2/4 < 3/4 < 4/4 = 17.00, P < .001). Patients with a score of 0-1/4, 2-3/4, and 4/4 had a median OS of greater than 312, of 183 and 106 months, respectively (HR0/4 < 1/4 < 2/4 < 3/4 < 4/4 = 13.69, P = .001). This score will help to identify, among the good and poor prognosis subgroups, patients who will need early therapy and thus will require a closer follow-up. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: miRs: fine-tuning prognosis in CLL Deepa Sampath and George A. Calin Blood 2009 113: 5035-5036. [Full Text] [PDF] This article has been cited by other articles: R. Visone, L. Z. Rassenti, A. Veronese, C. Taccioli, S. Costinean, B. D. Aguda, S. Volinia, M. Ferracin, J. Palatini, V. Balatti, et al. Karyotype-specific microRNA signature in chronic lymphocytic leukemia Blood, October 29, 2009; 114(18): 3872 - 3879. [Abstract] [Full Text] [PDF] D. Sampath and G. A. Calin miRs: fine-tuning prognosis in CLL Blood, May 21, 2009; 113(21): 5035 - 5036. [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020