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 Blood, 28 May 2009, Vol. 113, No. 22, pp. 5624-5627.
Prepublished online as a Blood First Edition Paper on March 31, 2009; DOI 10.1182/blood-2008-12-193748.

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TRANSFUSION MEDICINE

Brief report

Regulatory T-cell status in red cell alloimmunized responder and nonresponder mice

Weili Bao1,*, Jin Yu1,2,*, Susanne Heck3,*, and Karina Yazdanbakhsh1

1 Laboratory of Complement Biology, New York Blood Center, NY; 2 Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China; and 3 Flow Cytometry Laboratory, New York Blood Center, NY

Red blood cell alloimmunization remains a major complication for transfusion-dependent patients, but immune factors governing risk for alloimmunization are unknown. We hypothesized that CD4+ regulatory T cells (Tregs), which we have shown control the rate and the frequency of red blood cell alloimmunization in mouse models, may dictate responder/nonresponder status. Using a transfusion regimen in which more than 50% of mice develop alloantibodies to human glycophorin A antigen, we found reduced in vitro and in vivo Treg-suppressive activity in responders compared with nonresponders that was the result of impaired Treg suppressor function. Moreover, responders were prone to developing additional alloantibodies to strong immunogens, whereas nonresponders were resistant to alloimmunization. Altogether, our data raise the possibility that Treg activity may be used as a marker for identifying responder/nonresponder status in transfusion recipients.


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