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Blood, 28 May 2009, Vol. 113, No. 22, pp. 5635-5643. Prepublished online as a Blood First Edition Paper on January 23, 2009; DOI 10.1182/blood-2008-08-173658. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-08-173658v1 113/22/5635    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Opiela, S. J. Articles by Adkins, B. Search for Related Content PubMed PubMed Citation Articles by Opiela, S. J. Articles by Adkins, B. Related Collections Hematopoiesis and Stem Cells Immunobiology Transplantation Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants Shannon J. Opiela1, Tulay Koru-Sengul2, and Becky Adkins1 Departments of 1 Microbiology and Immunology and 2 Epidemiology and Public Health, Miller School of Medicine, University of Miami, FL In contrast to adults, the murine neonatal CD4+ compartment contains a high frequency of recent thymic emigrants (RTEs). However, the functional capabilities of these cells in neonates are relatively unknown. Moreover, it has not been determined whether RTEs from neonates and adults are comparable. Here we have directly compared neonatal and adult CD4+ RTEs for the first time, using a transgenic mouse strain that allows for the identification and purification of RTEs. Our data demonstrate that RTEs from murine neonates and adults are phenotypically and functionally distinct. In particular, although the magnitude of RTEs cytokine responses from both age groups is dependent on the conditions of activation, neonatal RTEs always exhibited higher levels of effector Th1/Th2 cytokine production than adult RTEs. In addition, neonatal, but not adult, RTEs showed early proliferation in response to stimulation with interleukin-7 alone. This was associated with faster kinetics of interleukin-7R down-regulation and higher levels of pSTAT5 in neonatal RTEs. These quantitative and qualitative differences in the neonatal and adult RTEs populations may at least partially explain the diverse responses that are elicited in vivo in neonates in response to different conditions of antigen exposure. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: RTEs: lazy T-cell teenagers Pamela J. Fink Blood 2009 113: 5374-5375. [Full Text] [PDF] This article has been cited by other articles: E. G. Houston Jr. and P. J. Fink MHC Drives TCR Repertoire Shaping, but not Maturation, in Recent Thymic Emigrants J. Immunol., December 1, 2009; 183(11): 7244 - 7249. [Abstract] [Full Text] [PDF] P. J. Fink RTEs: lazy T-cell teenagers Blood, May 28, 2009; 113(22): 5374 - 5375. [Full Text] [PDF]

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