SEARCH:   Advanced

Blood, 4 June 2009, Vol. 113, No. 23, pp. 5737-5742. Prepublished online as a Blood First Edition Paper on March 31, 2009; DOI 10.1182/blood-2009-02-204172. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2009-02-204172v1 113/23/5737    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Clifford, G. M. Articles by Franceschi, S. PubMed PubMed Citation Articles by Clifford, G. M. Articles by Franceschi, S. Related Collections Immunobiology Lymphoid Neoplasia Clinical Trials and Observations Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Hodgkin lymphoma in the Swiss HIV Cohort Study Gary M. Clifford1, Martin Rickenbach2, Mauro Lise3, Luigino Dal Maso3, Manuel Battegay4, Julia Bohlius5, Emmanuelle Boffi El Amari6, Urs Karrer7, Gernot Jundt8, Andrea Bordoni9, Silvia Ess10, Silvia Franceschi1, and for the Swiss HIV Cohort Study 1 International Agency for Research on Cancer, Lyon, France; 2 Coordination and Data Center, Swiss HIV Cohort Study, Lausanne, Switzerland; 3 Epidemiology and Biostatistics Unit, Aviano Cancer Center, Aviano, Italy; 4 Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland; 5 Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; 6 Geneva University Hospital, Geneva, Switzerland; 7 Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland; 8 Cancer Registry of Basel, Basel, Switzerland; 9 Cancer Registry of the Canton of Ticino, Locarno, Switzerland; and 10 Cancer Registry of St Gallen and Appenzell, St Gallen, Switzerland Hodgkin lymphoma (HL) risk is elevated among persons infected with HIV (PHIV) and has been suggested to have increased in the era of combined antiretroviral therapy (cART). Among 14 606 PHIV followed more than 20 years in the Swiss HIV Cohort Study (SHCS), determinants of HL were investigated using 2 different approaches, namely, a cohort and nested case-control study, estimating hazard ratios (HRs) and matched odds ratios, respectively. Forty-seven incident HL cases occurred during 84 611 person-years of SHCS follow-up. HL risk was significantly higher among men having sex with men (HR vs intravenous drug users = 2.44, 95% confidence interval [CI], 1.13-5.24) but did not vary by calendar period (HR for 2002-2007 vs 1995 or earlier = 0.65, 95% CI, 0.29-1.44) or cART use (HR vs nonusers = 1.02, 95% CI, 0.53-1.94). HL risk tended to increase with declining CD4+ cell counts, but these differences were not significant. A lower CD4+/CD8+ ratio at SHCS enrollment or 1 to 2 years before HL diagnosis, however, was significantly associated with increased HL risk. In conclusion, HL risk does not appear to be increasing in recent years or among PHIV using cART in Switzerland, and there was no evidence that HL risk should be increased in the setting of improved immunity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Degree of immune suppression and risk of HIV-related Hodgkin lymphoma: time points matter Riccardo Dolcetti, Paolo De Paoli, and Diego Serraino Blood 2009 114: 2354. [Full Text] [PDF] Response: Lymphocyte counts prior to Hodgkin lymphoma development Gary Clifford, Silvia Franceschi, and Martin Rickenbach Blood 2009 114: 2354-2355. [Full Text] [PDF] This article has been cited by other articles: R. Dolcetti, P. De Paoli, and D. Serraino Degree of immune suppression and risk of HIV-related Hodgkin lymphoma: time points matter Blood, September 10, 2009; 114(11): 2354 - 2354. [Full Text] [PDF] G. Clifford, S. Franceschi, and M. Rickenbach Response: Lymphocyte counts prior to Hodgkin lymphoma development Blood, September 10, 2009; 114(11): 2354 - 2355. [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020