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 Blood, 18 June 2009, Vol. 113, No. 25, pp. 6269-6270.

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InsideBlood

MYELOID NEOPLASIA

Comment on Garzon et al, page 6411

MicroRNA: mIR-ly regulators of DNMT?

Elizabeth A. Griffiths, and Steven D. Gore

JOHNS HOPKINS UNIVERSITY

Abstract

In this issue of Blood, Garzon and colleagues present evidence for a functional role of miR 29b in controlling DNMT levels in leukemia. Their work may provide insight into the mechanism of action of the azanucleotides and could potentially offer the first pharmacologically active miRNA.


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Related Article in Blood Online:

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
Ramiro Garzon, Shujun Liu, Muller Fabbri, Zhongfa Liu, Catherine E.A. Heaphy, Elisa Callegari, Sebastian Schwind, Jiuxia Pang, Jianhua Yu, Natarajan Muthusamy, Violaine Havelange, Stefano Volinia, William Blum, Laura J. Rush, Danilo Perrotti, Michael Andreeff, Clara D. Bloomfield, John C. Byrd, Kenneth Chan, Lai-Chu Wu, Carlo M. Croce, and Guido Marcucci
Blood 2009 113: 6411-6418. [Abstract] [Full Text] [PDF]





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