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 Blood, 18 June 2009, Vol. 113, No. 25, pp. 6273-6274.

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InsideBlood

RED CELLS & IRON

Comment on van Rooijen et al, page 6449

Dissecting VHL-associated pathologies

Eric Metzen, and Ulf Brockmeier

UNIVERSITY OF DUISBURG-ESSEN

Abstract

In this issue of Blood, van Rooijen and colleagues demonstrate that zebrafish carrying a mutation in the von Hippel Lindau gene (VHL) develop Chuvash polycythemia, a hereditary human disease characterized by the dysregulation of hypoxia-inducible proteins including erythropoietin.


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Related Article in Blood Online:

Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia
Ellen van Rooijen, Emile E. Voest, Ive Logister, Jeroen Korving, Thorsten Schwerte, Stefan Schulte-Merker, Rachel H. Giles, and Fredericus J. van Eeden
Blood 2009 113: 6449-6460. [Abstract] [Full Text] [PDF]





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