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Blood, 18 June 2009, Vol. 113, No. 25, pp. 6361-6371. Prepublished online as a Blood First Edition Paper on April 20, 2009; DOI 10.1182/blood-2008-12-192997. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-12-192997v1 113/25/6361    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Do, J.-s. Articles by Min, B. PubMed PubMed Citation Articles by Do, J.-s. Articles by Min, B. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and T cells in vivo Jeong-su Do1, and Booki Min1 1 Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, OH Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that T cells limit CD8 T-cell expansion but not the initial proliferation after transfer into lymphopenic recipients. Interleukin-15 (IL-15) produced by and trans-presented on the membrane of the CD11c+ dendritic cells (DCs) is the key factor that mediates homeostatic competition between CD8 and T cells, revealing previously unrecognized IL-15–dependent homeostatic mechanisms between different T-cell subsets in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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