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Blood, 18 June 2009, Vol. 113, No. 25, pp. 6477-6484. Prepublished online as a Blood First Edition Paper on March 3, 2009; DOI 10.1182/blood-2008-09-176594. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-09-176594v1 113/25/6477    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Clave, E. Articles by Toubert, A. PubMed PubMed Citation Articles by Clave, E. Articles by Toubert, A. Related Collections Transplantation Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation Emmanuel Clave1, Marc Busson1, Corinne Douay1, Régis Peffault de Latour2, Jeannig Berrou1, Claire Rabian1, Maryvonnick Carmagnat1, Vanderson Rocha2, Dominique Charron1, Gérard Socié2,3, and Antoine Toubert1 1 Laboratoire d'Immunologie et d'Histocompatibilité, Assistance Publique-Hôpitaux de Paris (AP-HP), Inserm Unite Mixte de Recherche (UMR) 940, Institut Universitaire d'Hématologie, Université Paris-Diderot, Paris; 2 Service d'Hématologie-Greffe de Moelle, Hôpital Saint-Louis, AP-HP, Paris; and 3 Inserm Unité 728, Institut Universitaire d'Hématologie, Paris, France Long-term T-cell reconstitution after hematopoietic stem cell transplantation (HSCT) is dependent on patient thymic function and affected by graft-versus-host disease (GVHD). To assess the impact of acute GVHD (aGVHD) on thymic function, we followed a cohort of 93 patients who received HSCT from a human histocompatibility leukocyte antigen-identical sibling, mainly for hematologic malignancies. Thymic output was measured by signal-joint T-cell receptor excision circles (sjTREC) real-time polymerase chain reaction. Absolute sjTREC number was lower at 6 months in patients with aGVHD (P = .014), associated with lower absolute counts of naive CD4 T cells at 6 and 12 months (P = .04 and .02), and persistent abnormalities in T-cell repertoire diversity. Age and aGVHD affected thymic function independently in multivariate analysis. In patients less than 25 years of age, thymic function recovered almost totally at 1 year. As a marker of thymocyte proliferation, we quantified the βTREC generated during the T-cell receptor β-chain recombination, in a group of 20 age-matched patients. Mean βTREC level was reduced at 6 months in patients with aGVHD, indicating an impact on early thymic differentiation rather than on intrathymic proliferation. These data show that aGVHD or its treatment has a transient impact on thymic function in younger patients in the first months after HSCT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Is a little GVHD a good thing? Terry J. Fry Blood 2009 113: 6274-6275. [Abstract] [Full Text] [PDF] This article has been cited by other articles: T. J. Fry Is a little GVHD a good thing? Blood, June 18, 2009; 113(25): 6274 - 6275. [Abstract] [Full Text] [PDF]

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