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Blood, 25 June 2009, Vol. 113, No. 26, pp. 6611-6618. Prepublished online as a Blood First Edition Paper on April 24, 2009; DOI 10.1182/blood-2009-01-198028. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2009-01-198028v1 113/26/6611    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Fenoglio, D. Articles by Zocchi, M. R. PubMed PubMed Citation Articles by Fenoglio, D. Articles by Zocchi, M. R. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY V1 T lymphocytes producing IFN- and IL-17 are expanded in HIV-1–infected patients and respond to Candida albicans Daniela Fenoglio1, Alessandro Poggi2, Silvia Catellani3, Florinda Battaglia1, Alessandra Ferrera1, Maurizio Setti4, Giuseppe Murdaca5, and Maria Raffaella Zocchi6 1 Centre of Excellence for Biological Sciences, University of Genoa, Genoa; 2 Laboratory of Immunology, National Institute for Cancer Research, Genoa; 3 Laboratory of Hematology, Department of Internal Medicine, 4 Department of Internal Medicine, and 5 Department of Semiotics, University of Genoa, Genoa; and 6 Division of Immunology, Transplants, and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy In early HIV-1 infection, V1 T lymphocytes are increased in peripheral blood and this is related to chemokine receptor expression, chemokine response, and recirculation. Herein we show that, at variance with healthy donors, in HIV-1–infected patients ex vivo–isolated V1 T cells display cytoplasmic interferon- (IFN-). Interestingly, these cells coexpress cytoplasmic interleukin-17 (IL-17), and bear the CD27 surface marker of the memory T-cell subset. V1 T cells, isolated from either patients or healthy donors, can proliferate and produce IFN- and IL-17 in response to Candida albicans in vitro, whereas V2 T cells respond with proliferation and IFN-/IL-17 production to mycobacterial or phosphate antigens. These IFN-/IL-17 double-producer T cells express the Th17 RORC and the Th1 TXB21 transcription factors and bear the CCR7 homing receptor and the CD161 molecule that are involved in T-cell transendothelial migration. Moreover, V1 T cells responding to C albicans express the chemokine receptors CCR4 and CCR6. This specifically equipped circulating memory T-cell population might play an important role in the control of HIV-1 spreading and in the defense against opportunistic infections, possibly contributing to compensate for the impairment of CD4+ T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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