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Blood, 25 June 2009, Vol. 113, No. 26, pp. 6707-6715. Prepublished online as a Blood First Edition Paper on March 4, 2009; DOI 10.1182/blood-2008-09-178095. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-09-178095v1 113/26/6707    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Robach, P. Articles by Cairo, G. PubMed PubMed Citation Articles by Robach, P. Articles by Cairo, G. Related Collections Red Cells, Iron, and Erythropoiesis Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS, IRON, AND ERYTHROPOIESIS Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin Paul Robach1, Stefania Recalcati2, Domenico Girelli3, Cecilia Gelfi4, Niels J. Aachmann-Andersen5, Jonas J. Thomsen5, Anne M. Norgaard5, Alessandra Alberghini2, Natascia Campostrini3, Annalisa Castagna3, Agnese Viganò4, Paolo Santambrogio6, Tibor Kempf7, Kai C. Wollert7, Stéphane Moutereau8, Carsten Lundby5,9,*, and Gaetano Cairo2,* 1 Département Médical, Ecole Nationale de Ski et d'Alpinisme, Chamonix, France; 2 Department of Human Morphology and Biomedical Sciences Città Studi, University of Milano, Milano, Italy; 3 Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy; 4 Department of Sciences and Biomedical Technologies, University of Milano, Segrate, Italy; 5 The Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark; 6 Proteomics of Iron Metabolism Unit, Department of Biotechnologies, San Raffaele Scientific Institute, Milano, Italy; 7 Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; 8 Laboratoire de Biochimie, Hôpital Henri-Mondor, Créteil, France; and 9 Department of Sport Science, University of Århus, Århus, Denmark The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia leads to skeletal muscle iron mobilization and decrease in myoglobin protein levels. To investigate the effect of enhanced erythropoiesis on systemic and muscle iron metabolism under nonhypoxic conditions, 8 healthy volunteers were treated with recombinant erythropoietin (rhEpo) for 1 month. As expected, the treatment efficiently increased erythropoiesis and stimulated bone marrow iron use. It was also associated with a prompt and considerable decrease in urinary hepcidin and a slight transient increase in GDF-15. The increased iron use and reduced hepcidin levels suggested increased iron mobilization, but the treatment was associated with increased muscle iron and L ferritin levels. The muscle expression of transferrin receptor and ferroportin was up-regulated by rhEpo administration, whereas no appreciable change in myoglobin levels was observed, which suggests unaltered muscle oxygen homeostasis. In conclusion, under rhEpo stimulation, the changes in the expression of muscle iron proteins indicate the occurrence of skeletal muscle iron accumulation despite the remarkable hepcidin suppression that may be mediated by several factors, such as rhEpo or decreased transferrin saturation or both. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Muscle iron in stress erythropoiesis? Marc Kerenyi and Ernst W. Müllner Blood 2009 113: 6507-6508. [Full Text] [PDF] This article has been cited by other articles: M. Kerenyi and E. W. Mullner Muscle iron in stress erythropoiesis? Blood, June 25, 2009; 113(26): 6507 - 6508. [Full Text] [PDF]

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