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 Blood, 15 January 2009, Vol. 113, No. 3, pp. 563-566.
Prepublished online as a Blood First Edition Paper on October 28, 2008; DOI 10.1182/blood-2008-06-162750.

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HEMATOPOIESIS AND STEM CELLS

Brief report

Both primitive and definitive blood cells are derived from Flk-1+ mesoderm

Jesse J. Lugus1,2,*, Changwon Park1,*, Yunglin D. Ma1,3, and Kyunghee Choi13

1 Department of Pathology and Immunology, 2 Molecular Cell Biology Program, and 3 Developmental Biology Program, Washington University School of Medicine, St Louis, MO

Emerging evidence suggests that all hematopoietic and endothelial cells originate from Flk-1+ mesoderm in the mouse. However, this concept has not been completely proven, especially for the origin of blood cells. Using either Flk1+/Cre;Rosa26R-EYFP or Flk1+/Cre;Rosa26R-LacZ mice, we permanently marked Flk-1+ cells and their progenies to determine the relationship between hematopoietic tissues and cells that express Flk-1. In embryos, all blood cells within the yolk sac and aorta were of Flk-1+ origin. In addition, nearly all CD45+ cells in bone marrow and circulating blood in adults were of Flk-1+ origin. These results provide clear evidence that all blood cells, primitive and definitive, in mice are derived from Flk-1+ mesodermal cells.


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