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 Blood, 22 January 2009, Vol. 113, No. 4, pp. 769-774.
Prepublished online as a Blood First Edition Paper on June 26, 2008; DOI 10.1182/blood-2008-02-139154.

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REVIEW ARTICLE

Life after the thymus: CD31+ and CD31– human naive CD4+ T-cell subsets

Siegfried Kohler1, and Andreas Thiel1,2

1 Clinical Immunology Group, Deutsches Rheuma-Forschungszentrum Berlin, Berlin; and 2 Regenerative Immunology and Aging, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

Early in life, thymic export establishes the size and the diversity of the human naive T-cell pool. Yet, on puberty thymic activity drastically decreases. Because the overall size of the naive T-cell pool decreases only marginally during ageing, peripheral postthymic expansion of naive T cells has been postulated to account partly for the maintenance of T-cell immunity in adults. So far, the analysis of these processes had been hampered by the inability to distinguish recent thymic emigrants from proliferated, peripheral, naive T cells. However, recently, CD31 has been introduced as a marker to distinguish 2 subsets of naive CD4+ T cells with distinct T-cell receptor excision circle (TREC) content in the peripheral blood of healthy humans. Here, we review studies that have characterized TREChi CD31+ thymicnaive CD4+ T cells and have accordingly used the assessment of this distinct subset of naive CD4+ T cells as a correlate of thymic activity. We will discuss further potential clinical applications and how more research on CD31+ thymicnaive and CD31– centralnaive CD4+ T cells may foster our knowledge of the impact of thymic involution on immune competence.


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This article has been cited by other articles:


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I. Bains, R. Thiebaut, A. J. Yates, and R. Callard
Quantifying Thymic Export: Combining Models of Naive T Cell Proliferation and TCR Excision Circle Dynamics Gives an Explicit Measure of Thymic Output
J. Immunol., October 1, 2009; 183(7): 4329 - 4336.
[Abstract] [Full Text] [PDF]


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