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 Blood, 29 January 2009, Vol. 113, No. 5, pp. 1071-1074.
Prepublished online as a Blood First Edition Paper on October 27, 2008; DOI 10.1182/blood-2008-07-166363.

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LYMPHOID NEOPLASIA

Brief Report

Gene expression profiling of peripheral T-cell lymphoma including {gamma}{delta} T-cell lymphoma

Kana Miyazaki1, Motoko Yamaguchi1, Hiroshi Imai2, Tohru Kobayashi1, Satoshi Tamaru1, Kazuhiro Nishii1, Masao Yuda3, Hiroshi Shiku4, and Naoyuki Katayama1

Departments of 1 Hematology and Oncology, 2 Pathologic Oncology, 3 Medical Zoology, and 4 Cancer Vaccine and Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Japan

The gene expression profile of peripheral {gamma}{delta} T-cell lymphoma ({gamma}{delta}TCL) has not been investigated. Using oligonucleotide microarrays, we analyzed total RNA from 7 patients with {gamma}{delta}TCL (4 hepatosplenic, 1 cutaneous, 1 intestinal, and 1 thyroidal) and 27 patients with {alpha}βTCL (11 peripheral TCL-unspecified, 15 angioimmunoblastic TCL, and 1 hepatosplenic). Unsupervised microarray analyses classified all hepatosplenic {gamma}{delta}TCLs into a single cluster, whereas other {gamma}{delta}TCLs were scattered within the {alpha}βTCL distribution. We identified a T-cell receptor signature gene set, which accurately classified {gamma}{delta}TCL and {alpha}βTCL. A classifier based on gene expression under supervised analysis correctly identified {gamma}{delta}TCL. One case of hepatosplenic {alpha}βTCL was placed in the {gamma}{delta}TCL grouping. {gamma}{delta}TCL signature genes included genes encoding killer cell immunoglobulin-like receptors and killer cell lectin-like receptors. Our results indicate that hepatosplenic {gamma}{delta}TCL is a distinct form of peripheral TCL and suggest that nonhepatosplenic {gamma}{delta}TCLs are heterogeneous in gene expression.


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