Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 29 January 2009, Vol. 113, No. 5, pp. 1167-1174.
Prepublished online as a Blood First Edition Paper on October 27, 2008; DOI 10.1182/blood-2008-06-161299.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2008-06-161299v1
113/5/1167    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tolar, J.
Right arrow Articles by Blazar, B. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tolar, J.
Right arrow Articles by Blazar, B. R.
Related Collections
Right arrow Hematopoiesis and Stem Cells
Right arrow Transplantation
Right arrowRelated Article in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

TRANSPLANTATION

Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells

Jakub Tolar1, Akemi Ishida-Yamamoto2, Megan Riddle1, Ron T. McElmurry1, Mark Osborn1, Lily Xia1, Troy Lund1, Catherine Slattery1, Jouni Uitto3, Angela M. Christiano4,*, John E. Wagner1,*, and Bruce R. Blazar1,*

1 Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis; 2 Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan; 3 Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA; and 4 Departments of Dermatology and Genetics & Development, Columbia University, New York, NY

The recessive dystrophic form of epidermolysis bullosa (RDEB) is a disorder of incurable skin fragility and blistering caused by mutations in the type VII collagen gene (Col7a1). The absence of type VII collagen production leads to the loss of adhesion at the basement membrane zone due to the absence of anchoring fibrils, which are composed of type VII collagen. We report that wild-type, congenic bone marrow cells homed to damaged skin, produced type VII collagen protein and anchoring fibrils, ameliorated skin fragility, and reduced lethality in the murine model of RDEB generated by targeted Col7a1 disruption. These data provide the first evidence that a population of marrow cells can correct the basement membrane zone defect found in mice with RDEB and offer a potentially valuable approach for treatment of human RDEB and other extracellular matrix disorders.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article in Blood Online:

Bone marrow cells can manipulate healing
Vincent Falanga
Blood 2009 113: 982-983. [Full Text] [PDF]





click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020