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Blood, 29 January 2009, Vol. 113, No. 5, pp. 1175-1183. Prepublished online as a Blood First Edition Paper on October 29, 2008; DOI 10.1182/blood-2008-05-158782. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-05-158782v1 113/5/1175    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rizzo, J. D. Articles by Deeg, H. J. Search for Related Content PubMed PubMed Citation Articles by Rizzo, J. D. Articles by Deeg, H. J. Related Collections Transplantation Free Research Articles Clinical Trials and Observations Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Solid cancers after allogeneic hematopoietic cell transplantation J. Douglas Rizzo1, Rochelle E. Curtis2, Gérard Socié3, Kathleen A. Sobocinski1, Ethel Gilbert2, Ola Landgren2, Lois B. Travis4, William D. Travis5, Mary E. D. Flowers6, Debra L. Friedman6, Mary M. Horowitz1, John R. Wingard7, and H. Joachim Deeg6 1 Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; 2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; 3 Hôpital Saint Louis, Paris, France; 4 James P. Willmot Cancer Center, Rochester, NY; 5 Memorial Sloan-Kettering Cancer Center, New York, NY; 6 Fred Hutchinson Cancer Research Center, Seattle, WA; and 7 Shands Hospital, Gainesville, FL Transplant recipients have been reported to have an increased risk of solid cancers but most studies are small and have limited ability to evaluate the interaction of host, disease, and treatment-related factors. In the largest study to date to evaluate risk factors for solid cancers, we studied a multi-institutional cohort of 28 874 allogeneic transplant recipients with 189 solid malignancies. Overall, patients developed new solid cancers at twice the rate expected based on general population rates (observed-to-expected ratio 2.1; 95% confidence interval 1.8-2.5), with the risk increasing over time (P trend < .001); the risk reached 3-fold among patients followed for 15 years or more after transplantation. New findings showed that the risk of developing a non–squamous cell carcinoma (non-SCC) following conditioning radiation was highly dependent on age at exposure. Among patients irradiated at ages under 30 years, the relative risk of non-SCC was 9 times that of nonirradiated patients, while the comparable risk for older patients was 1.1 (P interaction < .01). Chronic graft-versus-host disease and male sex were the main determinants for risk of SCC. These data indicate that allogeneic transplant survivors, particularly those irradiated at young ages, face increased risks of solid cancers, supporting strategies to promote lifelong surveillance among these patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Incidence of second cancers after allogeneic hematopoietic stem cell transplantation using reduced-dose radiation Matthew M. Hsieh, Courtney D. Fitzhugh, and John F. Tisdale Blood 2009 114: 225. [Full Text] [PDF] Response:Solid cancers after allogeneic hematopoietic cell transplantation J. Douglas Rizzo, Rochelle E. Curtis, H. Joachim Deeg, and Lois B. Travis, on behalf of the coauthors Blood 2009 114: 225-226. [Full Text] [PDF] This article has been cited by other articles: M. M. Hsieh, C. D. Fitzhugh, and J. F. Tisdale Incidence of second cancers after allogeneic hematopoietic stem cell transplantation using reduced-dose radiation Blood, July 2, 2009; 114(1): 225 - 225. [Full Text] [PDF] J. D. Rizzo, R. E. Curtis, H. J. Deeg, L. B. Travis, and on behalf of the coauthors Response:Solid cancers after allogeneic hematopoietic cell transplantation Blood, July 2, 2009; 114(1): 225 - 226. [Full Text] [PDF] B. N. Savani, S. Goodman, and A. J. Barrett Can Routine Posttransplant HPV Vaccination Prevent Commonly Occurring Epithelial Cancers after Allogeneic Stem Cell Transplantation? Clin. Cancer Res., April 1, 2009; 15(7): 2219 - 2221. [Abstract] [Full Text] [PDF]

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