SEARCH:   Advanced

Blood, 5 February 2009, Vol. 113, No. 6, pp. 1225-1230. Prepublished online as a Blood First Edition Paper on October 22, 2008; DOI 10.1182/blood-2008-08-174128. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-08-174128v1 113/6/1225    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lijfering, W. M. Articles by van der Meer, J. Search for Related Content PubMed PubMed Citation Articles by Lijfering, W. M. Articles by van der Meer, J. Related Collections Free Research Articles Thrombosis and Hemostasis Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Clinical relevance of decreased free protein S levels: results from a retrospective family cohort study involving 1143 relatives Willem M. Lijfering1, Rene Mulder1, Min Ki ten Kate1, Nic J. G. M. Veeger1,2, Andre B. Mulder1, and Jan van der Meer1 1 Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, and 2 Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands Conflicting data have been reported on the risk for venous thrombosis in subjects with low free protein S levels. We performed a post-hoc analysis in a single-center retrospective thrombophilic family cohort, to define the optimal free protein S level that can identify subjects at risk for venous thrombosis. Relatives (1143) were analyzed. Relatives with venous thrombosis (mean age 39 years) had lower free protein S levels than relatives without venous thrombosis (P < .001), which was most pronounced in the lowest quartile. Only relatives with free protein S levels less than the 5th percentile (< 41 IU/dL) or less than the 2.5th percentile (< 33 IU/dL) were at higher risk of first venous thrombosis compared with the upper quartile (> 91 IU/dL); annual incidence 1.20% (95% confidence interval [CI], 0.72–1.87) and 1.81% (95% CI, 1.01–2.99), respectively; adjusted hazard ratios 5.6, (95% CI, 2.7–11.5) and 11.3 (95% CI, 5.4–23.6). Recurrence rates were 12.12% (95 CI, 5.23–23.88) and 12.73% (95% CI, 5.12–26.22) per year; adjusted hazard ratios were 3.0 (95% CI, 1.03–8.5) and 3.4 (95% CI, 1.1–10.3). In conclusion, free protein S level can identify young subjects at risk for venous thrombosis in thrombophilic families, although the cutoff level lies far below the normal range in healthy volunteers. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Makris Thrombophilia: grading the risk Blood, May 21, 2009; 113(21): 5038 - 5039. [Full Text] [PDF] W. M. Lijfering, J.-L. P. Brouwer, N. J. G. M. Veeger, I. Bank, M. Coppens, S. Middeldorp, K. Hamulyak, M. H. Prins, H. R. Buller, and J. van der Meer Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives Blood, May 21, 2009; 113(21): 5314 - 5322. [Abstract] [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020