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 Blood, 19 February 2009, Vol. 113, No. 8, pp. 1829-1833.
Prepublished online as a Blood First Edition Paper on January 5, 2009; DOI 10.1182/blood-2008-05-155283.

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TRANSPLANTATION

Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens

Kazutoshi Aoyama1,2, Motoko Koyama2, Ken-ichi Matsuoka1, Daigo Hashimoto3, Tatsuo Ichinohe4, Mine Harada2, Koichi Akashi2, Mitsune Tanimoto1, and Takanori Teshima3

1 Biopathological Science, Okayama University Graduate School of Medicine and Dentistry, Okayama; 2 Department of Medicine and Biosystemic Science and 3 Center for Cellular and Molecular Medicine, Kyushu University Graduate School of Medical Science, Fukuoka; and 4 Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Exposure of offspring to noninherited maternal antigens (NIMAs) during pregnancy may have an impact on transplantations performed later in life. Using a mouse model, we recently showed that bone marrow transplantation (BMT) from NIMA-exposed offspring to the mother led to a reduction of graft-versus-host disease (GVHD). Since offspring can also be exposed to NIMAs by breastfeeding after birth, we tested whether breast milk could mediate the tolerogenic NIMA effect. We found that oral exposure to NIMAs by breastfeeding alone was sufficient to reduce GVHD, and that in utero exposure to NIMAs is required for maximum reduction of GVHD. The tolerogenic milk effects disappeared when donor mice were injected with CD25 monoclonal antibodies during the lactation period, suggesting a CD4+CD25+ regulatory T cell–dependent mechanism. Our results suggest a previously unknown impact of breastfeeding on the outcome of transplantation.


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P. Dutta, M. Molitor-Dart, J. L. Bobadilla, D. A. Roenneburg, Z. Yan, J. R. Torrealba, and W. J. Burlingham
Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice
Blood, October 22, 2009; 114(17): 3578 - 3587.
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