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 Blood, 26 February 2009, Vol. 113, No. 9, pp. 2038-2046.
Prepublished online as a Blood First Edition Paper on January 8, 2009; DOI 10.1182/blood-2008-06-162495.

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PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Essential role of spi-1–like (spi-1l) in zebrafish myeloid cell differentiation

Alex Bukrinsky1, Kevin J. P. Griffin2, Yan Zhao2, Shuo Lin2,3, and Utpal Banerjee13

1 Department of Biological Chemistry, 2 Department of Molecular, Cellular and Developmental Biology, and 3 Molecular Biology Institute, University of California Los Angeles

The ETS protein Spi-1/Pu.1 plays a pivotal and widespread role throughout hematopoiesis in many species. This study describes the identification, characterization, and functional analysis of a new zebrafish spi transcription factor spi-1–like (spi-1l) that is expressed in primitive myeloid cells, erythro-myelo progenitor cells, and in the adult kidney. Spi-1l functions genetically downstream of etsrp, scl, and spi-1/pu.1 in myeloid differentiation. Spi-1l is coexpressed in a subset of spi-1/pu.1 cells and its function is necessary and sufficient for macrophage and granulocyte differentiation. These results establish a critical role for spi-1l in zebrafish myeloid cell differentiation.


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