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 Blood, 3 September 2009, Vol. 114, No. 10, pp. 2009-2010.

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InsideBlood

GENE THERAPY

Comment on Mingozzi et al, page 2077

Muscling through AAV immunity

Thierry VandenDriessche

UNIVERSITY OF LEUVEN

Abstract

AAV-1 is one of the most promising vectors for gene delivery to skeletal muscle. In this issue of Blood, Mingozzi and colleagues now demonstrate that AAV-1–mediated gene transfer into human skeletal muscle results in activation of capsid-specific T cells.1


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Related Article in Blood Online:

AAV-1–mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells
Federico Mingozzi, Janneke J. Meulenberg, Daniel J. Hui, Etiena Basner-Tschakarjan, Nicole C. Hasbrouck, Shyrie A. Edmonson, Natalie A. Hutnick, Michael R. Betts, John J. Kastelein, Erik S. Stroes, and Katherine A. High
Blood 2009 114: 2077-2086. [Abstract] [Full Text] [PDF]





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